Anu, Sebastian (2017) Evaluation of Tocolytic Activity of Aqueous Seed Extract of Syzygium Cumini on Oxytocin Induced Preterm Labour. Masters thesis, KMCH College of Pharmacy, Coimbatore.
|
Text
260417_261525802.pdf Download (3MB) | Preview |
Abstract
Syzygium cumini is a well known bioactive plant which has been widely used for the treatment of various diseases in traditional and folk medicine. The present investigation was aimed to determine the tocolytic activity of the aqueous seed extract of Syzygium cumini (AESC) in animal models. The in vitro antioxidant activity of AESC was evaluated by DPPH and ABTS radical scavenging assay which showed the hydrogen donating and free radical scavenging activity of extract that aids in the prevention of preterm labour. In vivo tocolytic activity of AESC was evaluated. Group I was given normal saline, Group II oxytocin (1 IU) i.m, Group III atosiban (6mg/kg) i.p, Group IV AESC (200mg/kg) p.o and Group V AESC (400mg/kg), p.o. AESC shows significant reduction in the rate of preterm labour which was comparable with the standard treated group as well as the normal group. The level of in vivo antioxidant parameters such as catalase, SOD, and GSH were restored in the treated group compared to the control group. The study reveals that the extracts have been able to increase the endogenous antioxidant enzyme activities while reducing the lipid peroxidation. The AESC was subjected to pharmacological testing in vitro on a piece of isolated rat uterus previously pretreated with estradiol valerate, concentrations used were 25 mg/ml and 50 mg/ml. The concentrations (25 mg/ml) and (50 mg/ml) produce 50.9 % and 72.7 % inhibition respectively. In conclusion, the results indicate the presence of active principles in the aqueous seed extract of Syzygium cumini which may be responsible for the tocolytic activity.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Tocolytic Activity ; Aqueous Seed Extract ; Syzygium Cumini ; Oxytocin Induced Preterm Labour. |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Ravindran C |
| Date Deposited: | 08 Jan 2018 06:02 |
| Last Modified: | 13 Feb 2018 06:10 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/5354 |
Actions (login required)
 |
View Item |
