Mohammed Faseel, V P (2017) A Study on Antiurolithic and Antioxidant Activities of Glochidion Velutinum Leaves. Masters thesis, RVS College of Pharmaceutical Sciences, Coimbatore.
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Abstract
AIM AND OBJECTIVE: Most of the plants are used in the alternative system of medicine but they are not systematically standardised. According to WHO guideline all the customary drugs should be standardised before going for the formulation. One of the WHO assembly resolutions emphasized the need to ensure quality control of medicinal plants products using modern techniques and establishment of required standards of quality for herbal medicines. So the objective of the project is to evaluate the pharmacognostical and phytochemical characters’ of the selected plants by advanced techniques. Exploiting the leaves of glochidion velutinum Phytochemical, Pharmacological aspects with special emphasis on anti urolithiatic activity. SUMMARY:This present study evaluated Glochidion velutinum for urolithiasis and related problems in human. As conventional medicines are typically taken by the oral route, same course of administration was used for assessment of antilithiatic consequence of the extracts of Glochidion velutinum at a dose of 200mg/kg and Cystone herbal tablet at a dose of 100mg/kg aligned with ethylene glycol induced urolithiasis in rats. In the present study, male rats were selected to persuade urolithiasis because the urinal system of male rats resembles that of humans and also the quantity of stone deposition in female rats was drastically fewer. Substantiation in preceding studies indicated that in response to 14 day period of ethylene glycol (1% v/v) administration, young male albino rats form renal calculi encompassed mainly of calcium oxalate. The biochemical mechanisms for this progression are related to a raised in the urinal concentration of oxalate. Stone development in ethylene glycol fed animals is caused by hyperoxaluria, which causes augmented renal retention and emission of oxalate. In the present study oxalate and calcium excretion progressively augmented in calculi- induced animals, since it is customary that hyperoxaluria, is a far more risk reason in the pathogenesis of renal stones than hypercalciuria, and the changes in urinal oxalate levels are comparatively much more important than those of calcium. Augmented urinal calcium is a feature favouring the nucleation and precipitation of calcium oxalate (or) apatite (calcium phosphate) from urine and consequent crystal growth. Conversely, extracts of Glochidion velutinum treated animals lowered the levels of oxalate as well as calcium excretion.CONCLUSION: In the present study, Glochidion velutinum are having good antioxidant and antiurolithiatic activity, it was proved obviously in this juncture. Meticulous percevings of the patho-physiology of illness and method of action of these herbal medicines have great importance in improvement of effective and safe antiurolithiatic agent. The antioxidant action was calculated as free radical scavenging activity technique, Nitric oxide scavenging, DPPH method, Reducing control determination technique, Hydrogen peroxide method. All the methods depict good response due to thepresence of phenolic compounds and flavonoids in three species. The herbal drugs exert their urolithiatic consequence by varying the ionic content of urine lessening the ca+ and oxalate ion strength or escalating magnesium and citrate excretion and also with diuretic activity. In this respect this information provides a fruitful area for scientific research by willing investigators.An attempt may be made to develop new herbal formulation to treat Kidney stone by Glochidion velutinum plants. From this present study we can conclude by using this Glochidion velutinum, we can go for herbal formulation development to treat Kidney stone.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Antiurolithic ; Antioxidant Activities ; Glochidion Velutinum Leaves |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Ravindran C |
| Date Deposited: | 08 Jan 2018 06:03 |
| Last Modified: | 08 Jan 2018 06:03 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/5350 |
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