Helicobacter Pylori related Gastritis in Adults a Clinical, Endoscopic Histopathological and Rapid Urease Test Study.

Rajeswari, P (2011) Helicobacter Pylori related Gastritis in Adults a Clinical, Endoscopic Histopathological and Rapid Urease Test Study. Masters thesis, Thanjavur Medical College, Thanjavur.

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Abstract

The Understanding Of Etiopathogenesis Of Peptic Ulcer, Expressed As Gastritis, Gastric Ulcer, Duodenitis, Duodenal Ulcer Has Been Revolutionised During Last Decade With The Discovery In 1983, Of A New Pathogen Categorized As Helicobacter Pylori By Warren And Marshall. 67.68 Several Reports Have Subsequently Supported The Association Of H.Pylori As A Major Etiological Factor In The Development Of Peptic Ulcer Disease 50, 78 And Recent Reports Also Suggest Its Association With Gastric Carcinoma And Lymphoma.82,88 Bacterium Has Been Classified As Class I Definite Gastric Carcinogen To Human 77,83,97 A Prospective Study Of Adult Presenting With Upper Abdominal Pain,20 Dyspepsia, Vomiting, Haematemesis Is Undertaken To Evaluate The Relationship Of This Symptomcomplex To Inflammatory Gastroduodenal Lesions With Special Reference To H.Pylori Infection. The Clinical Endoscopic Findings, Rapid Urease Test And Histopathological Evaluation Of Gastric Antral Specimen With Special Stains 16 To Demonstrate The Organism Are Presented And Analysed. Regarding The Histopathology, Previous Studies On The Pathologic Changes Of Gastric Mucosa, Colonized By H.Pylori Have Markedly Focused On Inflammatory Reaction. In Addition To More Common Inflammatory Cell Infiltration It Is Only Recently The Histopathologic Effect Of H.Pylori On Gastric Epithelium At Light Microscopic Level Has Been Stressed And This Has Been Studied Systematically, Describing Striking Changes In Surface Epthelium And Attributing Them As Specific For H.Pylori Colonization And Correlating Them With Type Of Cytotoxin 30,17,18 ,Production And Risk Of Peptic Ulcer.50,53 H.Pylori Infection Can Be Diagnosed By Invasive 12,14,66 (Requiring Endoscopy) And Non Invasive Technique. 22,29,64 In This Study The Various Methods Of Identification Of H.Pylori And Histopathological Features Associated H.Pylori In Gastric Mucosa In Patients, Presenting With Dyspepsia Are Discussed And Described In Detail Paying Particular Attention To Histopathological Effects Of H.Pylori On Epithelial Cells And Evaluate The Gastric Mucosa As Per Updated Sydney System.23,24,70,88 In Addition, The Recent Literature Regarding Epidemiology, Clinical Features, Pathogenesis Of Infection Is Also Reviewed.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Helicobacter Pylori ; Gastritis ; Adults ; Clinical Endoscopic ; Histopathological ; Rapid Urease Test Study.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 29 Jun 2017 01:27
Last Modified: 29 Jun 2017 01:27
URI: http://repository-tnmgrmu.ac.in/id/eprint/533

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