Jegan, A (2016) A study on the prevalence of Vitamin D Deficiency and the effect of Vitamin D on the glycemic control and lipid profile in Type II Diabetes Mellitus patients in a rural tertiary care hospital. Masters thesis, Chennai Medical College Hospital and Research Centre, Trichy.
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Abstract
The World Health Organization (WHO) describes diabetes mellitus (DM) as a metabolic disorder of multiple etiology characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism resulting from defective insulin secretion, insulin action or both.Studies have been going on regarding the extra-skeletal diseases associated with vitamin D [25(OH)D]deficiency including T2DM(type2 diabetes mellitus). This study is aimed to evaluate the prevalence of vitamin D deficiency and the effect of vitamin D on the glycemic control and lipid profile in type II diabetes mellitus patients in a rural tertiary care hospital. Combinations of metformin and cholecalciferol significantly reduced fasting plasma glucose, postprandial plasma glucose,HbA1c,insulin resistance and serum triglyceride. Further this combination also showed insignificant reduction in total cholesterol, low density lipoprotein,(p ı 0.05), with a nonsignificant increase in high density lipoprotein as compared to metformin monotherapy in T2DM. A nonsignificant decrease in fasting serum insulin level and a significant increase in serum 25[OH] D level in T2DM with metformin and cholecalciferol therapy were observed.This study suggests vitamin D supplementation may improve glycemic control and lipid profile in T2DM.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Type 2 Diabetes Mellitus ; Metformin ; Vitamin D ; HbA1c ; Serum Insulin. |
| Subjects: | MEDICAL > Pharmacology |
| Depositing User: | Punitha K |
| Date Deposited: | 28 Jun 2017 09:16 |
| Last Modified: | 09 Dec 2018 05:23 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/532 |
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