Anoop, AP (2017) Studies on Neuroprotective Action of a Bioflavanoid in Lipopolysaccharide-Induced Inflammation. Masters thesis, J.K.K. Nattraja College of Pharmacy, Komarapalayam.
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Abstract
the present study could contribute to the evaluation of hesperidin against endotoxin-induced neurodegeneration and may shed an insight into the mechanism of action. Hence, a special attention is focused to understand the treatment of neurodegenerative diseases by natural flavonones, preferably hesperidin.There are, indeed, a multitude of paradigms assessing various aspects of the behavioral performance like anxiety and depression, changes in feeding pattern, body mass and biochemical analysis. Till now, some of the paradigms have not been used at all in the evaluation of hesperidin against behavioral consequences of adult rats when challenged with LPS.Hence, in order to contribute further to the knowledge of therapeutic effect of hesperidin, and its rich abundance, the objective of the present study is to subject hesperidin to test against endotoxin-induced neurodegeneration and in rat models. SUMMARY AND CONCLUSION: In conclusion, the present study demonstrated that many of the symptoms that characterized some forms of depression in humans are presented in experimental animals following oxidative stress induced by LPS administration and then following it with acute stress. These symptoms included reduced social, exploratory and locomotor activity. Moreover, chronic treatment with hesperidin for 30 days attenuated or completely abolished these symptoms. These findings extend several other lines of evidence for the association between immune activation and depression, which were mentioned in the introduction. This study also provides a leading experimentation concerning the protective in vivo effects of hesperidin on various systems associated with oxidative stress in endotoxemic rat brain + acute stress and, that may provide excellent protection against several neurodegenerative diseases among other disorders associated with oxidative stress. Our data support the potential value of these agents for the therapy of septic shock. Future studies should determine the molecular mechanisms that link LPSinduced HPA axis activation, physical stress and behavioral changes and the means by which hesperidin attenuate these responses. On the basis of published reports, and especially, on the ability of hesperidin to act as a potent anti-inflammatory agent, acting through diverse pathways, we can speculate that neuroprotective effects of hesperidin in LPS + acute stress-induced effects may be mediated by following distinct mechanisms: (1) inhibition of arachidonic acid metabolic pathways, PGE2 and down regulation of COX and LOX (2) ability to enhance enzymatic and nonenzymatic antioxidant status (3) ability to act as scavengers of HESPERIDIN, (4) ability to attenuate the LPS-induced activation of HPA-axis (5) ability to normalize the levels of biogenic and acetylcholine neurotransmitter systems in brain (6) inhibit NO production (7) may counter the LPS-induced alterations of neuroendocrine, neuroimmune and neurochemical functions and stress hormonal levels. The current report offers compelling, but perhaps not conclusive, arguments for an association between behavioral and brain anatomical changes induced by LPS and acute stress and its attenuation by hesperidin.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Neuroprotective Action ; Bioflavanoid ; Lipopolysaccharide; Induced Inflammation |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Ravindran C |
| Date Deposited: | 08 Jan 2018 08:17 |
| Last Modified: | 08 Jan 2018 08:17 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/5281 |
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