Molecular epidemiology of cryptosporidiosis and characterization of the human immune response to cryptosporidium spp. in Southern India.

Sitara Swarna Rao, A (2009) Molecular epidemiology of cryptosporidiosis and characterization of the human immune response to cryptosporidium spp. in Southern India. Doctoral thesis, Christian Medical College, Vellore.

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Abstract

Cryptosporidium spp. are apicomplexan parasites that are an important cause of diarrhea, both in children in developing countries, where it is endemic and in immunocompromised individuals where infection may result in protracted and life threatening diarrhea in HIV infected patients. In the west, cryptosporidiosis is causally associated with sporadic infections as well as waterborne outbreaks. In cryptosporidial infection, the immune status of the host plays an important role in determining disease. Immunocompetent persons develop a self-limited diarrheal illness but severe and persistent infections occur in subjects with compromised immune function. Cryptosporidiosis in humans is mainly attributable to 2 species - Cryptosporidium hominis and Cryptosporidium parvum. In this study, we have documented the prevalent species among children with diarrhea in the community in Vellore and in the hospital setting in Delhi, Trichy and Vellore. In children both in the community and among those coming to the hospital, C. hominis was the most common species with a few infections due to zoonotic species like C. parvum, C. felis and C. meleagridis. Most of the children with cryptosporidial diarrhea both in the community and in the hospital setting were under the age of 2 years. In the community, C. hominis-infected children had a significantly greater severity of diarrhea. Our findings indicate that hospitalization due to cryptosporidial diarrhea is mainly due to C. hominis, probably attributable to greater severity of disease with anthroponotic than zoonotic species.

Item Type: Thesis (Doctoral)
Uncontrolled Keywords: molecular epidemiology; cryptosporidiosis; characterization; human immune response; cryptosporidium spp.; India
Subjects: MEDICAL > Gastroenterology
Depositing User: Devi S
Date Deposited: 28 Jun 2017 07:44
Last Modified: 12 Jan 2018 05:51
URI: http://repository-tnmgrmu.ac.in/id/eprint/522

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