Amudhan Arvind, E (2016) A study on the effect of GRK5 Gln41Leu polymorphism on response to glucocorticoid therapy in bronchial asthma. Masters thesis, PSG Institue of Medical Sciences and Research, Coimbatore.
|
Text
2006012amudhanarvinde.pdf Download (21MB) | Preview |
Abstract
Asthma is a chronic inflammatory disease characterized by hyper-reactive airways causing recurrent episodes of wheezing, breathlessness and coughing, particularly at night or early in the morning. It has a familial preponderance with a polygenic inheritance. Various genetic alterations, single nucleotide polymorphisms (SNPs), are known to affect the effective management of asthma. One such polymorphism that has not been effectively explored is the G protein coupled receptor kinase5 (GRK5).This study aims to explore the effect of GRK5 polymorphism on the control and management of bronchial asthma in patients who are receiving inhaled corticosteroids Asthmatics with GRK5 polymorphism have a higher probability of requiring high dose steroids for adequate control of disease. GRK5 polymorphism does not have a significant effect on the duration of drug therapy. Though patients with polymorphism are expected to have poor control of their asthma, intake of high dose steroids may reverse the effect of the polymorphism and these patients may actually have adequate control of their disease. This study is the first of its type done in India - analysing the effect of GRK5 polymorphism on steroid therapy in asthmatics.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Bronchial Asthma ; GRK5 Polymorphism ; Dose; Duration ; Control ; Inhaled steroids |
| Subjects: | MEDICAL > Pharmacology |
| Depositing User: | Punitha K |
| Date Deposited: | 28 Jun 2017 07:35 |
| Last Modified: | 06 Nov 2018 19:38 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/521 |
Actions (login required)
 |
View Item |
