Appunni, S (2015) A study on prevalence of hyperhomocysteinemia and its correlation with carotid intima media thickness in ischemic stroke patients. Masters thesis, Stanley Medical College, Chennai.
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Abstract
Ischemic stroke is one of the common diseases found in medical wards, and is one of the common causes of morbidity and mortality worldwide. There are many causes of ischemic stroke and hyperhomocysteinemia is one of the documented causes. Homocysteine is synthesised in our body from methionine in a multistep process. Many vitamins like folic acid, vit B12, pyridoxine are involved in the homocysteine biosynthesis. Hyperhomocysteinemia is a proatherosclerotic state which is due to many pathological mechanisms. Homocysteine more than 15 μmol/L is taken as hyperhomocysteinemia. It has also been implicated in various other diseases like cardiovascular diseases, neuropsychiatric disorders, pregnancy complications, etc. There are many causes for hyperhomocysteinemia of which nutritional deficiencies and genetic causes are the most common. Treatment of hyperhomocysteinemia mainly involes nutritional supplementation with folic acid and Vit.B12, and others. Carotid intima media thickness (CIMT)measurement is accepted as a method to identify atherosclerosis, as increased CIMT has been found to be associated with increased cardiovascular and cerebrovascular complications. It is measured routinely by B-mode USG. CIMT has been found to be increased in hyperhomocysteinemia as well.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Hyperhomocysteinemia; Carotid Intima Media Thickness; Ischemic Stroke Patients |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Punitha K |
| Date Deposited: | 03 Jan 2018 11:20 |
| Last Modified: | 03 Jan 2018 11:20 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/5177 |
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