Elavarasi, P (2016) Efficacy and safety of ivabradine as an add-0n to atenolol in patients with chronic stable ischemic heart disease. Masters thesis, Tirunelveli Medical College, Tirunelveli.
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Abstract
Coronary artery disease is the leading cause of morbidity and mortality. Heart rate is the important key factor for determining the cardiac output ,myocardial oxygen demand and coronary blood flow . By the year 2020 , WHO predicts 13.2% death due to CAD . In india , 11% of urban population and 7% of the rural population had the prevalence of IHD. Reduction in heart rate is the main stay of treatment for preventing and treating the cardiovascular complications due to IHD. Pharmacotherapy of IHD are the conventional drugs like nitrates, beta blockers and calcium channel blockers . Due to the interactions with other drugs and adverse effects of the conventional drugs ,the management of IHD focused on novel targets . Ivabradine is a novel specific and selective If current inhibitor which slows the diastolic depolarization by acting on the SA node Ivabradine is safe and effective in preventing and treating further anginal attacks in patients with chronic stable ischemic heart disease already on atenolol therapy.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Ivabradine ; Ischemic Heart Disease ; Heart Rate ; Angina ; Ejection fraction. |
| Subjects: | MEDICAL > Pharmacology |
| Depositing User: | Punitha K |
| Date Deposited: | 28 Jun 2017 07:19 |
| Last Modified: | 06 Nov 2018 19:55 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/516 |
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