A Clinical Cytological Histomorphological Evaluation of Lymphnodes in Children.

Bagiyalakshmi, V (2006) A Clinical Cytological Histomorphological Evaluation of Lymphnodes in Children. Masters thesis, Thanjavur Medical College, Thanjavur.


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Lymph Node Enlargement Is A Common Feature Of A Variety Of Benign And Malignant Disorder That Affects Children. In Children Frequently We Encounter Enlarged Lymph Node, This Is Because The Immune System Of A Child Is Constantly Being Exposed To Antigens That Has Not Been Encountered Before. Most Of The Children Under Twelve Years Of Age Had Lymph Node Enlargement. 11 Majority Of Peripheral Lymphadenopathy Encountered (85% To 87%)64 In Children Are Benign In Nature And Self-Limiting. Whenever The Issue Of Malignancy Is Raised Or A Child Does Not Respond To Treatment, Morphological Analysis Of Lymph Node Is Inevitable. In Persistent Or Suspicious Lymphadenopathy There Is A Need For Rapid, Simple And Accurate Diagnostic Tool. The Diagnosis Of Lymphadenopathies With Fine Needle Aspiration Cytology Has Proven To Be Safe, Minimally Invasive, Cost Effective And Reliable Diagnostic Tool. Fine Needle Aspiration Cytology Has Become An Integral Part Of The Initial Diagnosis And Management Of Patients Presenting With Lymphadenopathy. This Simple Technique Has Recently Gained Wide Acceptance Since It Offers A High Degree Of Accuracy Lending Itself To Outpatient Diagnosis And Thus Making Considerable Saving In The Cost Of Hospitalization. Primary Tumour Of The Lymphatic Tissue Account For 3 – 5% Of Total Cancer Cases And Lymph Node Are A Common Site Of Metastasis For Different Cancer. Thus Clinical Recognition And Urgent Diagnosis Of Palpable Lymphadenopathy By Fine Needle Aspiration Cytology Is Of Great Importance. The Role Of Cytology In The Diagnosis Of Lymphoma Has Subsequently Become More Clearly Defined; It Is To Confirm A Clinical Suspicion Of Lymphoma Or To Exclude It With The Highest Possible Confidence. A Cytological Diagnosis Of NHL Is Confirmed By Open Biopsy And Histological Examination – Especially To Study The Growth Pattern And By Immune Marker Studies Necessary For Definite Diagnosis And Sub Typing. The Cytology And Histomorphological Correlation In A Proportion Of Cases Is Done To Assess The Sensitivity Of The Fine Needle Aspiration Cytology. False Positive And False Negative Results Were Compared With Other Studies And Literature. The Ever Increasing Number Of Commercially Produced Monoclonal Antibodies To Various Antigens, Specific To Different Cell Lines Is Proving Very Useful In Lymph Node Cytology. In Particular, It Assists The Pathologist In The Identification Of The Source Of Tumour Metastasis To Lymph Nodes And In The Distinction Between Undifferentiated Carcinoma, Malignant Melanoma And Malignant Lymphoma. In This Study, All Cases Of Non Hodgkin Lymphomas And Three Doubtful Cases Were Subjected To Immunohistochemistry For Confirmation And Further Sub Classification.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Clinical ; Cytological ; Histomorphological Evaluation; Lymphnodes ; Children.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 28 Jun 2017 08:13
Last Modified: 28 Jun 2017 08:13
URI: http://repository-tnmgrmu.ac.in/id/eprint/512

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