Benjamin, Jebaraj (2016) Validation of an algorithm to estimate vascular resistance and compliance in a perfused rat hind limb preparation. Masters thesis, Christian Medical College, Vellore.
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Abstract
OBJECTIVES : Validation of an algorithm to estimate vascular resistance and compliance using windkessel model of arterial system METHODS : Rats were anaesthetised, the abdominal organs were dissected and the descending aorta cannulated. The trunk was dissected below the level of diaphragm. The hindlimb preparation was then perfused with physiological ringer solution uisng an infusion pump. Pressure was recorded using a pressure transducer connected to CMCdaq data acquisition system. Since the flow rate of the infusion pump was known, the flow curve was derived. A beat to beat estimation of resistance and compliance was then obtained from the pressure recording using the estimated flow by windkessel method. Resistance was also calculated using the expression Mean Blood Pressure / Flow. RESULTS : The resistance estimated was compared to the values obtained form MBP/Flow. Pearson’s corellation coefficient between the two was 0.97 ± 0.04(n=6). The Mean Absolute Percentage Error of the estimated value was 8.9 ± 3.5%. A rat hindlimb preparation serves as a reliable experimental model for studying changes in vascular resistance and compliance.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Blood pressure ; resistance ; compliance ; windkessel. |
| Subjects: | MEDICAL > Physiology |
| Depositing User: | Subramani R |
| Date Deposited: | 01 Jan 2018 18:29 |
| Last Modified: | 01 Jan 2018 18:29 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/5023 |
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