Significance of HER-2/neu Overexpression in Oesophageal Carcinomas and It’s Correlation with the Histopathological Grading

Saranya, V (2016) Significance of HER-2/neu Overexpression in Oesophageal Carcinomas and It’s Correlation with the Histopathological Grading. Masters thesis, Coimbatore Medical College, Coimbatore.


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INTRODUCTION: Oesophageal carcinomas are one of the most aggressive human malignancies which are associated with a poor prognosis because most of the cases are in stage 2 or 3 at the time of diagnosis with a high frequency of lymph node metastases. It is important to know what prognostic factors can facilitate diagnosis, optimize therapeutic decisions, and improve the survival of these patients. A member of EGFR family, HER-2/neu is a very useful antigenic marker shown to be expressed in oesophageal carcinomas with increasing evidence of it’s therapeutic implications. AIM OF THE STUDY : Aim is to determine immunological expression of HER-2/neu in oesophageal carcinomas and correlate it with the histopathological grading. MATERIALS AND METHODS : This is a prospective study undertaken for a period of one year .Thirty cases of histologically proven oesophageal carcinomas were subjected for HER-2/neu immunoexpression. Membranous staining was considered as positive, intensity of staining was scored and compared with various histopathological parameters. RESULTS : HER-2/neu was positive in 41% of SCC and 67% of ADC.HER 2/neu positivity was observed in 66% of poorly differentiated SCCs , 58% in moderately differentiated SCCs and 11% in well differentiated SCCs. With respect to adenocarcinomas, 100% positivity in grade III tumours and 60% in grade II tumours was observed. There was significant correlation with grading, staging and lymph node metastases . Higher grade tumours had higher level of expression of HER-2/neu. CONCLUSION : It is concluded that HER-2/neu immunoexpression is significantly higher with progression of tumour grade . Hence, such patients with high grade and lymph node metastases could be benefitted with targeted therapy.

Item Type: Thesis (Masters)
Uncontrolled Keywords: oesophageal carcinomas ; HER-2/neu ; membranous.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 01 Jan 2018 17:14
Last Modified: 01 Jan 2018 17:14

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