Clinico-Pathological Study of Breast Carcinomas with ER, PR Studies.

Narmadha, R (2011) Clinico-Pathological Study of Breast Carcinomas with ER, PR Studies. Masters thesis, Kilpauk Medical College, Chennai.


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Breast Carcinoma Has A Major Impact On The Health Of Women. Cancer Of The Breast Is The Most Common Cancer Among Women In Many Regions In India And Has Overtaken Cancer Cervix (1). Presently 75,000 New Cases Occur In India Every Year. Breast Cancer Survival Is Linked To Early Detection And Timely Appropriate Treatment . Prognosis Is Related To A Variety Of Clinical, Pathological And Molecular Features Which Includes Stage Of The Carcinoma, Histologic Type, Grade And Lymph Node Metastasis . Estrogen And Progesterone Receptors Have, With Increasing Importance, Influenced The Management Of This Malignancy(2). With An Established Positive Correlation Of ER And PR With The Degree Of Tumour Differentiation, Determination Of ER And PR Status On Breast Biopsy Specimens, Prior To Therapeutic Intervention Is Advocated As A Standard Practice(3). Survival And Response To Hormone Therapy Are Most Favourable Among Women Who Are Receptor Positive. With These Prognostic Implications, The Need For Accurate And Precise Assessment Of ER And PR In Breast Carcinomas Is Essential To Predict The Response To Hormone Therapy. Immunohistochemistry Is The Most Commonly Used And The Best Method Of Testing ER And PR Status(4,16). This Study Is Aimed At Assessing The Hormone Receptor Status In Breast Carcinomas And To Correlate This Reactivity Pattern With Histologic Grade, Tumor Stage And Lymph Node Metastasis.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Clinico-Pathological; Breast Carcinomas; ER, PR Studies.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 28 Jun 2017 05:58
Last Modified: 28 Jun 2017 05:58

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