Sreekala, N P (2016) Evaluation of Wound Healing Effects of Leaf Extracts of Simarouba Glauca on Wistar Rats. Masters thesis, KMCH College of Pharmacy, Coimbatore.
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Abstract
The present investigation has been undertaken to study the wound healing properties of ethyl acetate and aqueous extracts of Simarouba glauca. The plant Simarouba glauca has a long history in herbal medicine in many countries. Experiments were conducted following standard procedures. Both extracts were evaluated for their in vitro anti oxidant, antimicrobial and cytotoxic properties. The EASG and AQSG ointments were administered topically, for evaluating the wound healing potential in excision wound model for fourteen days, in burn wound model for twenty one days, and in infected excision wound model for twenty one days. Povidone iodine was the standard for excision wound and silver sulfadiazine was used as the standard for both burn and infected excision wound models. Extracts treated groups showed higher in vitro antioxidant, anti microbial and cytoprotective activities. EASG exhibited similar wound healing activity that of the standard but with lesser magnitude.The result may be attributed to the phytoconstituents such as flavonoids and phenolics present in it which may be due to their individual or cumulative effect that enhanced wound healing and provided scientific evidence to the ethnomedicinal futures of Simarouba glauca. These findings could justify the inclusion of this plant in the management of wound healing.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Leaf Extracts ; Simarouba Glauca ; Wistar Rats ; EASG ; AQSG ; Wound healing potential ; Phytoconstituents. |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Ravindran C |
| Date Deposited: | 05 Jan 2018 05:49 |
| Last Modified: | 05 Jan 2018 08:06 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/4965 |
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