Nephroprotective Activity of Tamarindus Indica Linn Fruit Extract on Cisplatin Induced Nephrotoxicity in Rats

Danish, TK (2016) Nephroprotective Activity of Tamarindus Indica Linn Fruit Extract on Cisplatin Induced Nephrotoxicity in Rats. Masters thesis, The Erode College of Pharmacy and Research Institute, Erode.

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Abstract

AIM: The present study was focused on the investigation of Nephroprotective activity of the ethanolic extract of fruit pulp of Tamarindus indica Linn on cisplatin induced nephrotoxicity in Wistar albino rats. OBJECTIVES: The objectives of the present study were, Evaluation of Nephroprotective effect of EETI. Comparison of Nephroprotective effect of standard drug with toxic substance. Comparison of Nephroprotective effect of EETI with standard drug as well as toxic substance. Histopathological studies of all groups of animals to compare the histological damages. SUMMARY AND CONCLUSION:The present study was undertaken to scientifically evaluate the nephroprotective activity of the ethanolic extract of fruit pulps of Tamarindus indica Linn. The phytochemical investigation revealed the presence of carbohydrate, alkaloids, flavanoids, glycosides, saponins, tannins, phenols and anthroquinone in EETI. The administration of cisplatin during experimentation is effectively induced apoptosis and necrosis, which was similar to acute renal failure in human. Therefore it is an effective and an ideal model for nephrotoxicity research. The evaluation of renal parameters on nephrotoxic rats with EETI showed significantly elevate the attenuated body weight, urine volume, creatinine clearance and significant reduce in elevated serum creatinine level, which supports its Nephroprotective activity. The cisplatin induced rats showed elevated levels of serum blood urea nitrogen (BUN) and lipid peroxidation parameter like malondialdehyde (MDA) which was significantly decreased with treatment of EETI, which proves it having Nephroprotective activity. The Nephrotoxic rats also showed the reduced levels of enzymatic antioxidant like sulphoxide dismutase (SOD), glutathione peroxidise (GPx) and Catalase (CAT), and non-enzymatic antioxidant like Reduced glutathione (GSH), which was significantly increased with treatment of EETI, which showed its antioxidant activity due to the Flavonoids which is present in the extract. Histopathological studies on isolated kidney revealed that the EETI, reversed the kidney damage and also restored normal kidney architecture. In summary, the fruit pulp of Tamarindus indica Linn in an ethanolic extract showed statistically significant nephroprotective activity. The plant extract proved to have nephroprotective potentials may because of its known flavonoid contents and antioxidant properties. There is a scope for further investigation on the histopathology of liver and spleen and clinical studies that are required to elucidate the active phytoconstituents with potent nephroprotective activity.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Nephroprotective Activity ; Tamarindus Indica Linn Fruit Extract ; Cisplatin ; Nephrotoxicity ; Rats
Subjects: PHARMACY > Pharmacology
Depositing User: Ravindran C
Date Deposited: 05 Jan 2018 05:42
Last Modified: 05 Jan 2018 05:42
URI: http://repository-tnmgrmu.ac.in/id/eprint/4953

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