Aswin, L S (2016) Evaluation of Hepatoprotective Activity of Glycyrrhiza Glabra Linn on Paracetamol Induced Liver Damage in Rats. Masters thesis, J.K.K. Nattraja College of Pharmacy, Komarapalayam.
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Abstract
OBJECTIVE:Liver plays major role in detoxification and excretion of many endogenous and exogenous compounds, any injury to it or impairment of its functions may lead to many implications on ones health. Management of liver diseases is still a challenge to the modern medicine. Unfortunately, conventional or synthetic drugs used in the treatment of liver diseases are inadequate and sometimes can have serious side effects. In the absence of a reliable liver protective drug in modern medicine there are a number of medicinal preparations in ayurveda recommended for the treatment of liver disorders. In view of severe undesirable side effects of synthetic agents, there is growing focus to follow systemic research methodology and to evaluate scientific basis for the traditional herbal medicines that are claimed to possess hepatoprotective activity. Glycyrrhiza glabra Linn. (Family; Fabaceae) is a short lived, fast growing woody large herb. The green fruit contains papain similar to pepsin, pulp of the fresh fruit contain a soft yellow resin, fat, albuminoid sugar and pectin. Leaves contain an alkaloid called carpine and a glycoside named carposide. A properly ripened papaya is juicy, sweetish and somewhat like a cantaloupe in flavor. The fruits contain papain which helps in digestion and is used to tenderize meat. Fruit of Glycyrrhiza glabra Linn. is a rich source of vitamin C. It also contains vitamin E, pectin and carotinoids. Fruits, latex and juice of Glycyrrhiza glabra Linn. have been reported to be used in dyspepsia, intestinal irritation, habitual constipation and chronic diarrhoea. Traditionally, the leaf extract was used as a tonic for the heart, analgesia and treatment of stomachache. The extract is also known to have antioxidant properties. Glycyrrhiza glabra Linn. has been reported to be useful in liver ailments and has been shown to possess hepatoprotective activity against carbon-tetrachloride induced liver damage in experimental animals. But a systematic research on any possible effect of Glycyrrhiza glabra Linn. leaves on paracetamol induced hepatotoxicity seems to be scarce. Hence, it is decided to evaluate the hepatoprotective activity of Glycyrrhiza glabra Linn. leaves against paracetamol induced hepatotoxicity in albino wistar rats. CONCLUSION: In conclusion, the results of this study demonstrate that the methanol extract of Glycyrrhiza glabra Linn. leaves have a potent hepatoprotective action against paracetamol induced hepatic damage in rats. It’s mode in affording the hepatoprotective activity against paracetamol induced liver damage may be due to cell membrane stabilization, hepatic cell regeneration and enhancement of antioxidant enzymes such as catalase, superoxide dismutase and glutathione peroxidase production. In spite of the unknown mechanism of action, the obvious hepatoprotective effect of Glycyrrhiza glabra Linn. leaves on paracetamol induced liver damage may have potential in clinical applications. The hepatoprotective and antioxidant potential of extract could have been brought about by various phytochemical principles i.e flavonoids, alkaloids, phenolics and tannins present in Glycyrrhiza glabra Linn. leaves.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Hepatoprotective Activity ; Glycyrrhiza Glabra Linn ; Paracetamol Induced Liver Damage ; Rats |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Ravindran C |
| Date Deposited: | 05 Jan 2018 05:39 |
| Last Modified: | 05 Jan 2018 05:39 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/4946 |
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