Vishnupriya, K V (2017) Evaluation of Anti-Diabetic Activity of Ethanolic Extract of Leaves of Pouteria Campechiana (Kunth). Masters thesis, Annai J.K.K. Sampoorani Ammal College of Pharmacy, Komarapalayam.
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Abstract
AIM OF PRESENT STUDY: In recent year there has been a tremendous increase in demand for herbal drugs due to its safety, efficacy and better therapeutic results and also due to its economic pricing as compared to synthetic or allopathic drugs, which have several therapeutic complications. The selection of this plant, Pouteria campechiana was made on the basis of its High therapeutic value, Easy availability, Degree of research work which is not done Very less pharmacological studies have been carried out on the leaves of Hence, I have decided to choose the Pouteria campechiana project on Which detailed studies on Preliminary Phytochemical and Pharmacological activities of Oral glucose tolerance, and In-vivo Anti- diabetic studies is done. THE PLAN OF WORK: The plan of work for the study of Pouteria campechianacarried out as follow. Collection and authentication of raw material Preliminary phytochemical studies: Preparation of extract Qualitative phytochemical studies Pharmacological studies Acute oral toxicity study: Oral glucose tolerance test Screening of Anti- diabetic activity. In-vivo study of anti-diabetic activity (Alloxan induced diabetic in high fat diet Rats) SUMMARY AND CONCLUSION:The leaves of Pouteria campechiana belonging to the family sapotaceae has been examined to gain an insight of its phytochemical and pharmacological behavior. The preliminary phytochemical investigation of powdered Pouteria campechiana showed the presence of Carbohydrates, Alkaloids, Glycosides, Steroid, Terpenoids, Flavonoids, Proteins and Amino acids. The pharmacological and acute toxicity studies of ethanolic extract was performed by following, OECD-423 guidelines (Acute toxic class method). No mortality or acute toxicity was observed upto 2000mg/kg of body weight. The Biological dose of extract Pouteria campechiana dose was selected 200mg/kg and 400mg/kg in this dose possessed significant antidiabetic activity. Alloxan causes a massive destruction of β-cells of the isletsof langher-hans, resulting in reduced synthesis and release of insulin. The function of the insulin suppressed, which leads to high level of hyperglycemic and eventually to death,but the different extracts of pouteria campechiana showed antidiabetic effect in alloxan induced diabetic rats and reduced the mortality rate significantly. Overall, it can be concluded that ethanolic extract of Pouteria campechiana can be used as a natural source of anti-diabetic activity. Further pharmacological and biochemical studies are needed to isolate and characterize active compound responsible for the anti-diabetic activity.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Anti-Diabetic Activity ; Ethanolic Extract ; Leaves ; Pouteria Campechiana (Kunth). |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Ravindran C |
| Date Deposited: | 26 Dec 2017 02:19 |
| Last Modified: | 01 Feb 2018 17:17 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/4773 |
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