Ganesh Kumar, T (2017) Evaluation of Antidiabetic Activity of Ethanolic Extraction of Leaves of Rhinacanthus Nasutus (L.). Masters thesis, Annai J.K.K. Sampoorani Ammal College of Pharmacy, Komarapalayam.
|
Text
260417_261525706_GaneshKumar_T.pdf Download (2MB) | Preview |
Abstract
AIM OF PRESENT STUDY : In recent year there has been a tremendous increase in demand for herbal drugs due to its safety, efficacy and better therapeutic results and also due to its economic pricing as compared to synthetic or allopathic drugs, which have several therapeutic complications. The selection of this plant, Rhinacanthusnasutus was made on the basis of its High therapeutic value, Easy availability, Degree of research work which is not done Very less pharmacological studies have been carried out on the leaves of Hence, I have decided to choose the Rhinacanthus nasutus project on Which Rhinacanthus nasutus includes detailed studies on Preliminary Phytochemical and Pharmacological activities of Oral glucose tolerance, and In-vivo Anti- diabetic studies. SUMMARY AND CONCLUSION: The leaves of Rhinacanthus Nautus belonging to family Rhinacanthus Nasutus has been examined to gain an insight of its Phytochemical and pharmacological behaviors. The Pharmacognostical studies made on powdered Rhinacanthus Nasutus like ash value, loss on drying gave valuable information. Preliminary phytochemical investigation of showed the presence of Carbohydrate, Alkaloids, Phytosteroids, Flavonoids, Phenolic compounds and Tannins. The pharmacological and acute toxicity studies of ethanolic extract was performed by following, OECD-423 guidelines (Acute toxic class method). No mortality or acute toxicity was observed upto 2000mg/kg of body weight. The Biological dose of extract Rhinacanthus Nasutus dose was selected 200mg/kg and 400mg/kg in this dose possessed significant antidiabetic activity. In conclusion, in the present study on the ethanolic extract of Rhinacanthus Nasutus leaves having antidiabetic activity more over nearest activity ofGlibenclamide. This study shows that flavanoids present in this extract may bepossibly responsible for the antidiabetic activities. Histopathological studies on isolated pancreas revealed that ethanolic extract of Rhinacanthus Nasutus reversed the changes which produced due to diabetes caused by Alloxan. The normal pattern of histology of pancreas was observed.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Antidiabetic Activity ; Ethanolic Extraction ; Leaves ; Rhinacanthus Nasutus (L.). |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Ravindran C |
| Date Deposited: | 26 Dec 2017 02:21 |
| Last Modified: | 01 Feb 2018 16:37 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/4771 |
Actions (login required)
 |
View Item |
