Pattern of coagulation profile in patients with trauma.

Aanantha Lakshmi, B (2016) Pattern of coagulation profile in patients with trauma. Masters thesis, Chennai Medical College Hospital and Research Centre, Trichy.


Download (1MB) | Preview


Trauma is the fifth leading cause of death in individuals between age 5 and 45 years worldwide. It will become the second leading cause by 2020. Significant blood loss can occur due to traumatic coagulopathy caused by trauma, called “Acute Traumatic Coagulopathy”. This has been scantily described in the literature. Hence this study is aimed to study the effect of trauma on different parameters of coagulation profile and markers of fibrinolysis. 60 trauma patients between age 20 and 60 years were included. The incidence of coagulopathy was found to be 34% and overall mortality rate was 10.3 %. Association of variables like Tissue hypoperfusion, Severity of Injury, etc. with coagulopathy was proved to be statistically significant (p < 0.05). Association of the abovesaid variables with mortality was also studied and some were found to be significant. Those which were significant in univariate analysis were taken for multiple logistic regression analysis. Patients presenting with an established coagulopathy were likely to have poor outcomes, and hence must be identified as soon as possible and treated aggressively.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Trauma; Coagulopathy; Coagulation profile; Tissue hypoperfusion; Base deficit
Subjects: MEDICAL > Physiology
Depositing User: Punitha K
Date Deposited: 27 Jun 2017 12:01
Last Modified: 09 Aug 2017 05:27

Actions (login required)

View Item View Item