Morphometric Analysis of Histoarchitectural Changes in Cholecystitis

Priyadarshini, R (2017) Morphometric Analysis of Histoarchitectural Changes in Cholecystitis. Masters thesis, Tirunelveli Medical College, Tirunelveli.


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BACKGROUND : Cholecystitis appears to be increasing in incidence in India and western world. It is predominantly seen in fatty fertile forty years female. Based on the presence of gall stones, they are classified as calculous and acalculouscholecystitis. In this study, an attempt was made to morphometricallyanalyse thepredominant histoarchitecturalchanges in both calculous and acalculouscholecystitiswith comparison to normal human gall bladders received from autopsy subjects. METHODS : In the present study, 75cases and75 control gall bladder specimens were obtained, processedand stained with hematoxylin and eosin. After routine histopathological approach, they were subjected to morphometric analysis using IS capture software. Predominant histopathological alterations in various layers of gall bladder were studied and estimated in microns. Finally, the results were expressed in percentage with comparison to control groups. RESULTS : Our study showed female preponderance with M: F of 1:7.16. In both calculous and acalculouscholecystitis, changes like epithelial hyperplasia, erosion, intactness , lamina propria thickness, irregularity & gap, R.A sinus and inflammatory infiltrates in each layers were noted and estimated. On the behalf of statistical evidence, both calculousvs control and acalculousvs control are highly significant. CONCLUSION : In this morphometric study, all the predominant histopathological changes (except irregularity and gap) were found to be relatively more in calculouscholecystitis than acalculouscholecystitis with comparison to age and gender based control group which showed significantly minimal alterations.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Gall bladder ; cholecystitis ; gall stones ; acalculous ; morphometry.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 22 Dec 2017 17:13
Last Modified: 22 Dec 2017 17:13

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