Naveen Kumar, A S (2015) Formulation and Evaluation of Oral Disintegrating Tablets of an Anti Migraine Drug. Masters thesis, College of Pharmacy, Jaya College of Paramedical Sciences, Chennai.
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Abstract
In recent years, the importance of patient compliance,not only in drug efficacy but also in overall economicsof healthcare, has been increasingly recognized. Efforts toimprove patient compliance have included attempts toimprove the palatability of orally administered pharmaceuticalagents especially for children and elderly. Inparticular, a bitter taste is known to decrease patientcompliance, and thus reduce effective pharmacotherapy.Various techniques are used to mask the bitter taste of drug. In the present work, model drug is a moderately bitter drug,an attempt has been made to mask the taste of modeldrug by using sweetners like aspartame and mannitol in the formulation. The literature survey revealed that no work has been reported on ODT of the modeldrug OBJECTIVE:The main objective is to formulate ODT’S by using different superdisintegrants and sweetners in different ratio’s and evaluating its characteristics in order to improve the release rate,disintegration time, tastemasking and also providing better patient compliance.In vitro dissolution studies: 12 Dissolution study was conducted for formulations with different disintegrants using USP type-II apparatus (ELECTROLAB). The dissolution test was performed in buffers of different pH(0.1N HCl,6.8Phosphate buffer,4.5Acetate buffer, Water)50rpm and at a temperature of 370C±0.50C for 30 minutes. Ten milliliters of aliquots were periodically withdrawn at time intervals of 5, 10, 15, 20,and 30minutes. Then the sample volume was replaced with an equal volume of fresh dissolution medium. The samples were diluted and analyzed spectrophotometrically at 227nm.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Formulation and Evaluation of Oral Disintegrating Tablets of an Anti Migraine Drug |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 20 Dec 2017 07:22 |
| Last Modified: | 20 Dec 2017 10:57 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/4543 |
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