Sweetlin, S (2017) A Prospective Randomized Open Label Comparative Study of Montelukast and Ranitidine as an add on Therapy to Cetirizine in Chronic Urticaria. Masters thesis, Chengalpattu Medical College, Chengalpattu.
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Abstract
BACKGROUND : Chronic urticaria is a highly distressing disease affecting a person’s life quality. In most cases, monotherapy fails. Hence, combinations of antihistamines with montelukast, H2blockers, ciclosporin, dapsone, omalizumab are used with varying results. AIM : To assess the efficacy and safety of the combination therapy of Montelukast and Cetirizine with Ranitidine and Cetirizine in chronic urticaria patients. METHODOLOGY : Hundred patients were recruited, randomized and medications were given to group A (Cetirizine+ Montelukast) and group B (Cetirizine+Ranitidine).Complete history, clinical examination and laboratory investigations were done at the beginning of the study. Patients were educated to keep a daily record of Urticaria Activity Score(UAS7) over seven consecutive days in a descriptive chart. Review of patient’s UAS7 record and clinical examination were done at every weekend. Sum of score at the end of every week for 4 weeks were calculated and recorded. RESULTS : The mean weekly UAS in group A were 18.67, 10.07, 4.65, 1.74 and in group B were 27.77, 19.38, 13.68 and 8.04 respectively. Significant difference in symptom reduction between group A and group B was found to be favouring group A. The mean total UAS in group A was 35.13, group B is 68.87 (p< 0.001). CONCLUSION : Montelukast seems to be a promising medication as add-on therapy to Cetirizine both in the aspect of efficacy and safety in patients affected by chronic urticaria.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | chronic urticarial ; cetirizine ; montelukast ; ranitidine. |
| Subjects: | MEDICAL > Pharmacology |
| Depositing User: | Subramani R |
| Date Deposited: | 19 Dec 2017 14:08 |
| Last Modified: | 19 Dec 2017 14:08 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/4505 |
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