Jayakumar, K S (2017) Development of Lipid Based Tetrahydrocurcumin Nutricosmetics: Investigation of Essential Oil as Preservation Sysyem. Masters thesis, PSG College Of Pharmacy, Coimbatore.
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Abstract
AIM AND OBJECTIVES: Lipid based formulations usually contain lipid (soild or liquid) dispersed in aqueous solution of surfactant (or co-surfactant). Nano structured lipid carriers are proved to be suitable carriers with various advantages like (i) controlled release of the drug (ii) increased drug stability (iii) high drug loading (iv) no bio toxicity of the carrier (v) avoidance of organic solvents and (vi) no problems with respect to large scale production and sterilization. But, they often show poor stability due to microbial growth. Moreover, the problem of bacterial resistance to conventional preservatives has been observed in recent years. Traditionally used chemical preservatives often cause skin irritation and lead to allergenic reactions. All these factors have contributed to a search for alternative preservative systems. Hence, there is a lacuna to identify a natural preservative which can enhance the stability of lipid based formulations. These natural lipids (oils) have high oxidative resistance and are biocompatible, with no deleterious effects on the skin. The exotic fats used in skin care are known to exhibit their effects through restoration of a sufficient layer of skin lipids and skin elasticity, boost natural skin regeneration and increased skin hydration by forming an inert, epicutaneous occlusive membrane. Besides these facts, cocoa butter, mango butter, mineral and petroleum which is one of several exotic fats is viewed as an ingenious replacement for chemicals based lipid fat because of its appreciable contents which are very important as source of skin active ingredients. Furthermore, using of natural surfactants is viewed as alternative to replace helping to reduce contamination of the environment with drug particles. Like conventional properties offers exceptional surfactant blends with a balanced combination and dermatological properties in cosmeceuticals products. Therefore, the suitable use of a base surfactant or a cosurfactant in cosmetic cleansing preparations is attractive in the recent past. Natural surfactants show a lower irritation potential in comparison to other surfactants and confirming the excellent suitability. An idea of natural preservatives seems to be very promising and practical in terms of availability and eco friendly nature. Nowadays much attention has been focused on essential oils (EOs) that demonstrate antimicrobial activities and have been proposed as natural preservatives. Recent studies provided evidence that different mechanisms are involved in antibacterial activity of essential oils (EOs). EOs is usually considered safe due to their natural origin. Although most EOs is regarded as safe, some of them may cause risk of irritation, sensitization, phototoxicity or allergic reactions including anaphylaxis. EOs are also effective in controlling bacterial and fungicidal activity, which is an important criteria of a preservative. Growing demands for more natural and preservative- free cosmetics promoted an idea of the replacement of synthetic preservatives with essential oils (EOs) of antimicrobial properties. The antimicrobial effect of essential oil depends on content, concentration and interactions between the main active compounds. Effective preservatives should be characterized by a broad spectrum of antimicrobial activity at a minimum concentration. Based on these facts, the aim of this work is to develop a natural preservative system using essential oils with antimicrobial activity to enhance the preservation of nutricosmetics which are prepared using natural lipids and surfactants. For this purpose, nanostructured lipid carriers of tetrahydrocurcumin would be prepared with using essential oils with enhanced stability. The project would be carried out with the following objectives: To screen out various essential oils for their antimicrobial activity and evaluation of their minimum inhibitory concentration against different bacterial strains. To develop nano structural lipid carriers (NLC’s) and lipid based cream of Tetrahydrocurcumin (THC). To characterize and optimize the NLCs and lipid based cream of Tetrahydrocurcumin. To evaluate the stability of the NLCs and lipid based cream. To evaluate the antimicrobial activity of NLCs and lipid based cream of Tetrahydrocurcumin.SUMMARY AND CONCLUSION: Generally, lipid based formulations often show poor stability due to microbial growth. The problem of bacterial resistance to conventional preservatives has been observed in recent years. In the current study, an attempt was made to enhance the stability of THC loaded lipid based formulations for nutricosmeceutical purpose using a natural preservation system.THC loaded nanostructured lipid carriers were prepared to serve as a carrier to enhance the bioavailability of THC for nutraceutical purpose and lipid based cream loaded with NLCs of THC were prepared to serve as a carrier for the delivery of THC for cosmetic purpose. Initially, essential oils like cinnamon oil, peppermint oil, eucalyptus oil, lavender oil, clove oil, lemon grass oil, castor oil, neem oil and their mixtures were evaluated for antimicrobial activity. The results indicated a better antimicrobial property for cinnamon oil. Hence, THC loaded nanostructured lipid carriers and the corresponding creams were prepared using cinnamon oil as liquid oil carrier. THC loaded NLC were prepared from Cocoa butter, cinnamon oil and Soya lecithin by hot homogenization technique using ultra probe sonicator. The spherical shaped nanostructure lipid particles with a particle size of 55 nm showed a sustained release pattern across pig ear skin for around 96 % for 48 hours. The antimicrobial activity was studied by disc diffusion study, TNC 4 has good activity against gram positive (E.coli) and gram negative (S.aureus) bacterial strains These THC loaded nanostructure lipid particles were loaded in a lipid based cream (prepared from Cocoa butter, Cinnamon oil, Soya Lecithin). Evaluation of the texture properties of the lipid cream loaded with THC NLCs showed good firmness and stickiness. THC NLCs and lipid based cream loaded with THC NLCs showed good stability during the initial 3 months without any microbial contamination. Long term stability studies are in progress to evaluate the stability of the lipid based formulations for a period of 1 year. Lipid based nutricosmeceuticals prepared using cinnamon oil as a liquid oil can be a good promising natural preservative against microbial contamination and can possibly enhance the stability of several other lipid based nutricosmeceuticals loaded with different types of drugs.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Lipid Based Tetrahydrocurcumin Nutricosmetics ; Preservation Sysyem |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 19 Dec 2017 11:18 |
| Last Modified: | 19 Dec 2017 11:18 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/4489 |
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