Karthi, R (2017) Formulation and Evaluation of Ciprofloxacin Hydrochloride Floating Tablets using Natural Polymers. Masters thesis, J.K.K. Nattraja College of Pharmacy, Kumarapalayam.
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Abstract
AIM AND OBJECTIVE: The aim of the present work is to formulate and evaluate floating tablet of ciprofloxacin hydrochloride using natural polymers like xanthan gum and guar gum. Ciprofloxacin hydrochloride is a second generation fluroquinolone antibiotic. It inhibits the replication of DNA interfering with the action of DNA gyrase. It is weakly acidic drug and half life of 4 hours. According to BCS classification, ciprofloxacin hydrochloride coming under class4 category which has low solubility and low permeability. Ciprofloxacin is a FDA approved oral antibiotic drug, which has rapid and complete absorption after oral administration. Gastro –retentive delivery is one of the site specific delivery for the delivery of drug either at stomach or intestine. As ciprofloxacin hydrochloride has higher absorption site in the upper gastrointestinal tract and poor absorption in colon, suggest it is an ideal candidate for a gastroretentive drug-delivery system that will prolong the gastric residence time of the dosage form, giving prolonged drug release in the upper gastrointestinal tract, where absorption of ciprofloxacin hydrochloride is well confined. A systemic approach for design and development of gastroretensive drug delivery system of ciprofloxacin using polymers which increases the gastric residence time, decreases the diffusion distance and allow more of the antibiotic to penetrate through the gastric mucus layer and act locally at the infectious site to enhance the bioavailability and therapeautic efficacy of the drug. Naturally occurring polymers is preferred for controlled formulation because of its low cost, naturally available, biocompatible and better patient tolerance as well as public acceptance. So planned to formulate and evaluate floating tablets of ciprofloxacin hydrochloride using natural polymers. SUMMARY AND CONCLUSION: The main objective of the present study was to develop floating formulation containing 250 mg of ciprofloxacin hydrochloride for twice therapy using natural polymers like xanthan gum and guar gum. GRDDS improved the bioavailability and therapeutic efficiency of drug. In the preformulation, FTIR study was carried out for pure drug (ciprofloxacin hydrochloride), ciprofloxacin hydrochloride and excipients. It has not shown any interaction. Hence drugs were found to be compatible with excipients. The formulations were prepared by direct compression method. The angle of repose values for formulations range from 25.04±0.02 to27.10 ±0.06. Bulk and tapped densities were used for the measurement of compressibility index. The bulk and tapped values for formulations range from 0.25±0.05 to 0.33±0.04 and 0.32±0.04 to 0.38±0.02 respectively the car’s index and harusner’s ratio values for formulations range from 1.05±0.03 to 1.37±0.05 respectively. Thus all formulations exhibited good flow characteristics. The prepared floating tablets were evaluated for various parameters like thickness, weight variation, hardness, friability and drug content uniformity. The thickness of tablets in all formulations were ranged from 3.2±0.16 to 3.3±0.14. The weight variation of tablets in all formulations were ranged from 318±1.6 to 320±6.1. The hardness and friability of all the formulations F1-F9 was found to be 4.0±0.6 to 4.1±0.4 and 0.11 to 0.26 respectively. Drug content of all the formulations were ranging from 95.14±0.23 to 97.23±0.22. The buoyancy lag time of all the formulations were ranging from 45sec to 90sec. Compared to all formulations F4 showed the best buoyancy lag time, the buoyancy lag time for F4 was found to be 45sec. Total floating time of all formulations was found to be >8 hrs. The formulation containing xanthan gum shows the higher swelling compared to that of the formulations containing both xanthan and guar gum alone.The prepared tablets were then subjected to dissolution test for evaluating the invitro drug release. The dissolution studies were carried out in 0.1N hydrochloric acid in USP-32 appatarus at 37±0.5°C. The results of the dissolution studies indicated that the polymer concentration was having a substantial effect on the drug release from the tablets. Formulation F4 gave better controlled drug release and floating properties in comparision to the other formulations. This formulation took 45sec to become buoyant. The kinetic study was carried out for F4 formulation which showed that the drug release followed zero order kinetics followed by non-fickian diffusion. The stability studies were carried out for F4 formulation at 45°C 175% RH for 3months. Data revelead that there was no considerable difference. From the above study, concluded that F4 was the optimized formulation which has shown better buoyancy time 45sec and drug release 99.80% in 8hrs. However, further invivo studies can be carried out to support the results. The overall results explained that the tablets prepared by combination of xanthan gum and guar gum could be more effective on floating tablets and has shown more sustained effect than floating tablets containing natural polymer alone.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Ciprofloxacin ; Hydrochloride Floating Tablets ; Using Natural Polymers |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 19 Dec 2017 07:22 |
| Last Modified: | 19 Dec 2017 07:22 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/4469 |
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