Correlation between total leucocyte count, microalbuminuria and cardiovascular risk in type 2 diabetes mellitus: A Cross sectional study

Pradeepa, M (2016) Correlation between total leucocyte count, microalbuminuria and cardiovascular risk in type 2 diabetes mellitus: A Cross sectional study. Masters thesis, Tirunelveli Medical College, Tirunelveli.

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Abstract

BACKGROUND: Cardiovascular disease is the leading cause of death in the world. The mortality rate due to cardiovascular risk is six times more pronounced in individuals with diabetes mellitus than in others. So we have to diagnose the cardiovascular risk at an earlier date to prevent the onset of complications. AIMS AND OBJECTIVES: 1. To find the correlation between total leucocyte count, microalbuminuria and cardiovascular risk in type 2 diabetes mellitus. 2. To evaluate other risk factors of diabetes like increased BMI, waist circumference, family history, and smoking with microalbuminuria, leucocyte count and cardiovascular risk. MATERIALS AND METHODS: After getting institutional ethical committee 200 diabetic individuals of both men and women between ages 35-55 years were selected. Exclusion criteria includes type 1 diabetes mellitus, known malignant disease, after vigorous exercise, history of heart disease, urinary tract infection, liver cirrhosis, haematological diseases, advanced renal dysfunction(serum creatinine >2.0mg/dl), those taking medications like steroid and anti allergy agents. Parameters like blood pressure, waist circumference, BMI, total leucocyte count, fasting blood sugar, HbA1C, urine for microalbuminuria and ECG changes were recorded in a master chart in two groups microalbuminuria group and normoalbuminuria group. Results analysed using mean, standard deviation, correlation was calculated using spearman rho correlation. RESULTS: The prevalence of microalbuminuria was 33%, increased leucocyte count was found 27%, and ECG changes were found in 24%. There is a significant correlation between microalbuminuria, total leucocyte count. Microalbuminuria was associated with increased blood pressure, smoking, HbA1C, fasting blood sugar. CONCLUSION: Since there exists a correlation between total leucocyte count, microalbuminuria, and cardiovascular risk, total leucocyte count can also be used as a simple and cost effective method to detect the microvascular and macrovascular complications earlier thereby reducing the mortality and morbidity associated with complications.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Type 2 Diabetes Mellitus ; Microalbuminuria ; Total Leucocyte Count ; Cardiovascular Risk.
Subjects: MEDICAL > Physiology
Depositing User: Punitha K
Date Deposited: 27 Jun 2017 10:39
Last Modified: 22 Dec 2018 09:22
URI: http://repository-tnmgrmu.ac.in/id/eprint/444

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