Nasreen Shafieqa, S (2017) A Study of Maternal Serum Cystatin C and Serum Creatinine levels in Preeclamptic and Normotensive Pregnancies: A Case Control study. Masters thesis, Kilpauk Medical College, Chennai.
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Abstract
BACKGROUND : Preeclampsia, a syndrome characterized by hypertension, proteinuria and systemic vasoconstriction, is one of the leading causes of maternal and fetal morbidity. Altered renal function is an essential component of the pathophysiology of preeclampsia, which could lead to acute renal failure- an important cause for maternal morbidity and mortality. Majority of deaths due to preeclampsia and eclampsia are avoidable through early diagnosis and treatment of acute renal failure. Creatinine is unable to detect reduced GFR in early stages of kidney dysfunction hence the search for new biomarker like Cystatin C. Serum cystatin C is extremely sensitive to minor changes in GFR in the earliest stages of kidney disease. AIMS AND OBJECTIVES : 1. To estimate serum cystatin C and serum creatinine level in pre-eclamptic primigravidae and compare it with controls. 2. To assess the diagnostic performance of serum Cystatin C in early detection of renal dysfunction in pre-eclamptic primigravidae by comparing it with serum Creatinine. METHODS : A case control study was conducted among 40 preeclamptic and 40 normotensive term primigravidae and the values of serum creatinine and serum cystatin C were compared. RESULTS : Serum cystatin C concentrations were significantly higher in preeclamptic patients (0.895 ±0.310mg/L) compared to the normotensive females (0.489 ± 0.064 mg/L) whereas serum creatinine levels did not show significant difference between the two groups. CONCLUSION : Serum cystatin C appears to be a superior marker of renal function compared to serum creatinine in patients with preeclampsia and should be routinely included in the investigative work-up of these patients.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Maternal Serum Cystatin C ; Serum Creatinine levels ; Preeclamptic ; Normotensive Pregnancies ; Case Control study. |
| Subjects: | MEDICAL > Obstetrics and Gynaecology |
| Depositing User: | Subramani R |
| Date Deposited: | 18 Dec 2017 17:13 |
| Last Modified: | 18 Dec 2017 17:13 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/4422 |
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