A Histopathological Study of Malignant Round Blue Cell Tumors with Immunohistochemical Evaluation.

Viswanathan, K (2011) A Histopathological Study of Malignant Round Blue Cell Tumors with Immunohistochemical Evaluation. Masters thesis, Madurai Medical College.

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Abstract

Malignant Round Blue Cell Tumors Comprise A Diverse Group Of Diagnostically Challenging Primitive (Or) Undifferentiated Neoplasms Which Composed Of Small Cells With Uniform Round Nuclei And Scanty Cytoplasm Have Been Referred As Small-Cell, Round-Cell, Or Blue Cell Tumors. “Round” Refers To Uniform Shape Of The Nuclei, “Blue” To Colour Of The Nuclei On Routine Hematoxylin And Eosin Staining And “Small” To The Relative Lack Of Cytoplasm. The “Small Cells” Of Small Cell Tumors Are Larger Than Most Inflammatory Cells84. The Tumors Included In This Category Of Neoplasms Are As Follows13, 49,74,81,83, 1. Non Hodgkin’s Lymphoma 2. Ewing’s Sarcoma /Primitive Neuroectodermal Tumor (PNET) 3. Embryonal And Alveolar Rhabdomyosarcoma 4. Wilm’s Tumor 5. Neuroblastoma 6. Desmoplastic Small Round Cell Tumor (DSRCT) 7. Mesenchymal Chondrosarcoma 8. Small Cell Osteosarcoma 9. Small Cell Carcinoma 10. Malignant Rhabdoid Tumor 11. Myxoid Chondrosarcoma 12. Poorly Differentiated Synovial Sarcoma 13. Round Cell Liposarcoma 14. Epithelioid Sarcoma With Rhabdoid Phenotype 15. Retinoblastoma 16. Medulloblastoma Immunohistochemistry (IHC) And Molecular Diagnostics Have Greatly Improved Our Ability To Differentiate The Various Tumors And Classify Some Of These Tumors10, 81. Use Of The Special Diagnostic Techniques Have Become Increasingly Important In Diagnosis, Evaluation Of Recurrent Or Metastatic Disease, And In Some Cases For Prognostic Classification. These Are Always To Be Interpreted After Careful Evaluation Of The Light Microscopic Findings. However, The More We Use These Tools Diagnostically, The More It Becomes Apparent That These Special Techniques Have Pitfalls Of Their Own43,56. Finally, Additional Techniques Such As Flow Cytometry, Electron Microscopy And Molecular Analysis May Be Required For Final Confirmation Of The Diagnosis (Or) To Provide Prognostic Information52, 53.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Histopathological ; Malignant Round Blue Cell Tumors ; Immunohistochemical Evaluation.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 27 Jun 2017 11:26
Last Modified: 27 Jun 2017 11:26
URI: http://repository-tnmgrmu.ac.in/id/eprint/440

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