Heleena, Moncy Thomas (2016) Effect of pH And Polyvalent Cations on the Y-Site Incompatibility of Continuous Intravenous Infusions of Selected Critical Care Drugs in the Medical Intensive Care Unit. Masters thesis, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore.
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Abstract
Present study BACKGROUND: Critically ill patients in the Medical Intensive Care Unit (MICU) require multiple medications, often administered as continuous intravenous infusions. Two or more medications that are administered via Y-site connector mix in the lumen of the tubing prior to being infused into the patient. However, not all medications can be physically mixed together. The potential complications of co-administration of incompatible medications include precipitation, central venous catheter occlusion requiring additional venous access, reduced potency of medication, therapeutic failure and local and systemic inflammatory reactions. Various factors such as solvents, diluents, infusion fluids, pH of each drug, duration of stability and concentration of the selected critical care drugs play a major role in determining the compatibility of intravenous drug infusions at the Y-junction. OBJECTIVES: To study the influence of polyvalent ions in the co-infused drug solutions and acid-base reactions between the continuously infused drug solution and Y-site administered drug on the physicochemical compatibility of various critical care drugs used in the Medical Intensive Care Unit. To identify the most frequent and clinically significant incompatibilities of continuous IV infusions of the selected critical care drugs with Y-site administered drugs in the MICU settings STUDY DESIGN: Prospective observational study STUDY DURATION: 10 months (from November 2015 to August 2016). indicating the compatibility of selected continuous intravenous infusions with Y-site administered drugs commonly used in the MICU. CONCLUSION: The present study helps in the identification of the factors causing incompatibility of continuous intravenous infusions and Y-site administered drugs in the Medical Intensive Care Unit. The proposed study reviewed the compatibility of continuous intravenous infusions of certain selected critical care drugs against Y-site administered drugs with a view to improving the safety of multidrug therapy in the Medical Intensive Care Unit. The study also lead to the development of a two dimensional Y-site compatibility chart for commonly used critical care drugs in the Medical Intensive Care unit.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Polyvalent Cations ; Y-Site Incompatibility ; Intravenous Infusions ; Critical Care Drugs ; Medical Intensive Care Unit |
| Subjects: | PHARMACY > Pharmacy Practice |
| Depositing User: | Ravindran C |
| Date Deposited: | 18 Dec 2017 07:50 |
| Last Modified: | 18 Dec 2017 07:50 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/4390 |
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