A Clinicopathological Study of Ovarian Tumors and The Role of Immunohistochemical Proliferative Marker Ki 67.

Lavanya, R (2012) A Clinicopathological Study of Ovarian Tumors and The Role of Immunohistochemical Proliferative Marker Ki 67. Masters thesis, Madurai Medical College.

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Abstract

Like The Everyform Of Cancer, Early Detection Is What All About.. It Can Be Prevented With Testing And It Can Be Beaten If Caught Early! -Rod Stewart The Ovarian Tumors Are Not A Single Entity, But A Complex Wide Spectrum Of Neoplasms Involving A Variety Of Histological Tissues, Ranging From Epithelial Tissues, Connective Tissues, Specialized Hormone Secreting Cells To Germinal And Embryonal Cells.40 The Ovary Is Complex In Its Embryology, Histology, Steroidogenesis And Has Potential To Develop Malignancy40. Of All The Gynecologic Cancers, The Ovarian Malignancies Represent The Greatest Challenge Because The Ovary Gives Rise To Greater And Larger Variety Of Tumors Than Any Other Organ.A Female’s Risk At Birth Of Having Ovarian Tumor Sometime In Her Life Is 6- 7%,Of Having Ovarian Cancer Is Almost 1.5% And Dying From Ovarian Cancer Is 1%49 The Incidence Of Ovarian Cancer Ranks Below Only To The Carcinoma Of Cervix.The Ovarian Tumors Constitute About 5% Of Gynaecological Admissions. About 75% Of Them Are Benign And 25% Are Malignant. In India, Ovarian Tumors Account For 8% Of All Gynecological Malignancies43 Different Tumors Tend To Involve Different Age Groups.They Occur In Perimenopausal And Postmenopausal Women, Infrequently In Children Also. The Risk Of Developing Ovarian Tumor Peaks In The Fifth Decade Of Life88. The Ovarian Tumors Pose A Special Diagnostic And Management Problem In The Postmenopausal Women Because Of Their Late Presentation , High Risk Of Malignancy And Poor Prognostic Outcome And In Children Pose A Great Challenge To The Clinicians Owing To The Need Of Conservation Of Reproductive, Endocrinal And Menstrual Function On One Hand And Malignant Potential On The Other. Apart From Primary Tumors, Ovaries Are Frequent Site For Metastatic Involvement From Organs Like Stomach, Colon And Breast Signs And Symptoms Of Ovarian Cancer Are Frequently Absent Or Subtle Early On , Or Persist For Several Months Before Being Recognized And Diagnosed. More Than 50% Of Patients Are Diagnosed In The Advanced Stage Of The Disease. This Study Is Undertaken To Analyze The Histopathological Spectrum And Clinical Features And To Emphasize The Importance Of Immunohistochemical Markers In Accurate Diagnosis And To Investigate The Biological Significance Of Ki 67 Antigen Expression In Benign, Borderline And Malignant Ovarian Tumors.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Clinicopathological ; Ovarian Tumors ; Immunohistochemical ; Proliferative Marker Ki 67.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 27 Jun 2017 11:27
Last Modified: 27 Jun 2017 11:27
URI: http://repository-tnmgrmu.ac.in/id/eprint/438

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