Sakthivel, S (2017) A Study on Vitamin B12 Deficiency in Chronic Metformin Therapy in Type 2 Diabetes Mellitus patients in GMKMCH, Salem. Masters thesis, Government Mohan Kumaramangalam Medical College, Salem.
|
Text
200101017sakthivel.pdf Download (2MB) | Preview |
|
|
Text
200101017sakthivel_abstract.pdf Download (7kB) | Preview |
Abstract
BACKGROUND AND OBJECTIVE : The prevalence of vitamin B12 deficiency varies from 5.8 % to 30% among patients undergoing long-term treatment with metformin. DESIGN : Cross sectional study. METHODS : Patients with Type 2 diabetes were selected based on inclusion and exclusion criteria. Basic biochemical investigation with peripheral smear done. Serum B12 assay were done. Vitamin B12 deficiency is defined as values <180pg/ml. Association between vitamin B12 deficiency with duration of metformin therapy, duration of diabetes, with age, sex were done. RESULTS : The mean vitamin B12 level is low as the duration of metformin treatment increases. The sex, age relation with development of vitamin B12 deficiency was not significant. Mean MCV is higher in the Vitamin B12 deficient group. Macrocytosis is mainly noted in the vitamin B12 deficient group. CONCLUSION : Vitamin B12 deficiency occurs in type 2 diabetes mellitus patients treated with long-term metformin. The duration of metformin therapy significantly affects the development of vitamin B12 deficiency. Macrocytosis occurs in vitamin B12 deficient diabetic patients treated with metformin.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | vitamin b12 ; metformin. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 18 Dec 2017 03:16 |
| Last Modified: | 18 Dec 2017 03:16 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/4379 |
Actions (login required)
 |
View Item |
