Steroid induced Hyperglycemia during First 48 Hours of Steroid Therapy in Hospitalised Patients

Sailendri, G (2017) Steroid induced Hyperglycemia during First 48 Hours of Steroid Therapy in Hospitalised Patients. Masters thesis, Kilpauk Medical College, Chennai.


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INTRODUCTION : As hyperglycemia is an independent predictor of increased mortality in hospitalized patients with a range of co-morbidities, including an exacerbation of chronic obstructive lung disease, we conducted this descriptive study. AIM : To see for the occurrence of hyperglycemia within 48 hours in hospitalized patients started on corticosteroid therapy with respect to the nature of corticosteroid used and presence of risk factors for diabetes. METHODS : The study was a longitudinal descriptive study. It was conducted at Government Royapettah Hospital attached to Govt. Kilpauk Medical College. Data were collected from Medical wards in Govt. Royapettah Hospital. Totally 100 patients of bronchial asthma / chronic obstructive pulmonary disease started on oral / parentral corticosteroid therapy were included in this study from April 2016 to September 2016. The occurrence of hyperglycemia within 48 hours of steroid therapy & the other outcomes were assessed. RESULTS : Of 100 patients admitted, 38% were given Hydrocortisone, 38% Dexamethasone & 24% Prednisolone. The capillary blood glucose level after administration of the drug is highest (191.47) with Hydrocortisone > (162.47) with Dexamethasone > (152.42) with Prednisolone especially at the 12th hour. CONCLUSION : Hydrocortisone has highest capillary blood glucose level rise. Oral form of steroid (prednisolone) is best when compared to parentral forms. The risk factors HbA1C, Systolic BP, Waist Circumference are found to have significant correlation.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Steroid induced Hyperglycemia ; First 48 Hours ; Steroid Therapy ; Hospitalised Patients.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 18 Dec 2017 02:53
Last Modified: 18 Dec 2017 02:53

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