A study of auditory brainstem response and oxidative stress in individuals with vitiligo

Latha, K (2016) A study of auditory brainstem response and oxidative stress in individuals with vitiligo. Masters thesis, Stanley Medical College, Chennai.


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Vitiligo is an idiopathic, acquired, hypomelanotic, systemic disorder, affecting the whole pigmentary system including the stria vascularis of the inner ear, characterized by depigmented patches of different sizes and shapes in the skin resulting from the loss of functional melanocytes and melanin from the epidermis. Vitiligo occurs worldwide with a prevalence of 0.1% to 0.2 %. In India, the prevalence is 3% to 4%. Vitiligo commonly begins in childhood or young adulthood, with peak onset of age being 10 to 30 years, but it may occur at any age. All races are affected. Both gender are equally affected. Approximately 20% of individuals with vitiligo have atleast one first degree relative with vitiligo. The etiology of vitiligo is still not known, but several theories have been proposed to explain the melanocyte destruction like genetic, neural, cytotoxic and autoimmune theories. Oxidative stress has been implemented in the pathophysiology of vitiligo. During oxidative stress, the molecular oxygen is reduced to form superoxide radicals. Further, superoxide radicals dismutate to hydrogen peroxide, either spontaneously or by the action of superoxide dismutase Audiological changes in vitiligo subjects confirm that the vitiligo represents a systemic disease with widespread involvement of body melanocytes. The reduced levels or reduced activities of these melanocytes or both may be the cause for audiological abnormalities. Also, the antioxidant level was decreased in vitiligo subjects when compared with that of the controls suggesting a state of oxidative stress in them.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Brainstem Evoked Response Audiometry ; Brainstem Auditory Evoked Potential ; Vitiligo ; Superoxide dismutase enzyme ; Oxidative stress.
Subjects: MEDICAL > Physiology
Depositing User: Punitha K
Date Deposited: 27 Jun 2017 09:18
Last Modified: 09 Dec 2018 05:46
URI: http://repository-tnmgrmu.ac.in/id/eprint/436

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