Histopathological Study of Prostatic Lesions and Assessement with Agnor Index and Prostatic Basal Cell Marker.

Subathra, K (2012) Histopathological Study of Prostatic Lesions and Assessement with Agnor Index and Prostatic Basal Cell Marker. Masters thesis, Madurai Medical College.

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Abstract

“When The Hair Becomes Grey And Scant, When Specks Of Earthly Matter Begin To Be Deposited In The Tunics Of Artery, And When There Is Formed A White Zone Around The Cornea, At The Same Time, I Dare Say Invariably The Prostate Increases In Volume”. - Sir Benjamin Brodie. The Prostate Is A Pear Shaped Glandular Retroperitoneal Organ Encircling The Neck Of The Bladder And Urethra. It Weighs About 20 Gram In Normal Adult Male. The Prostate Is A Functional Conduit That Allows Urine To Pass From The Urinary Bladder To The Urethra, And Adds Nutritional Secretions To The Sperm To Form Semen During Ejaculation. Prostatic Secretion Contributes 20% Of Total Volume Of Semen. It Includes Spermine, Citric Acid, Cholesterol, Phospholipids, Fibrinolysin, Fibrinogenase, Zinc And Acid Phosphatase. Prostatic Diseases, Benign And Malignant Are Collectively Responsible For Significant Morbidity And Mortality In Men Throughout The World. The Ability Of This Small Gland To Cause Misery For Aging Male As A Consequence Of Bladder Obstruction Is Astonishing. Only Three Pathologic Processes Affect The Prostate Gland With Sufficient Frequency To Merit Discussion Namely Inflammation, Benign Prostatic Hyperplasia (BPH) And Tumours. Inflammation Of Prostate Is Called As Prostatitis. Prostatitis May Be Divided Into Several Categories Such As Acute Bacterial Prostatitis, Chronic Bacterial Prostatitis, Chronic Abacterial Prostatitis And Granulomatous Prostastitis. Benign Prostatic Hyperplasia (BPH) Is An Extremely Common Disorder In Men Over Age 50.77 It Is Characterized By Hyperplasia Of Prostatic Stromal And Epithelial Cells, Resulting In The Formation Of Large, Fairly Discrete Nodules In The Periurethral Region Of The Prostate. Prostate Cancer Is Now The Sixth Most Common Cancer In The World92. Prostatic Adenocarcinoma Is The Second Most Common Cause Of Cancer Mortality In Men Next To Lung Cancer. When The Terms "Prostate Cancer" Or "Prostate Adenocarcinoma" Are Used Without Qualifications It Refers To The Common Or Acinar Variant Of Prostate Cancer. In Approximately 70% Of Cases, Carcinoma Of The Prostate Arises In The Peripheral Zone Of The Gland, Classically In A Posterior Location, Where It May Be Palpable On Rectal Examination. Prostatic Cancers Are Diagnosed By Fine Needle Aspiration Cytology, Needle Biopsies, Transurethral Resection Of Prostate (TURP) And Prostatectomy. Interpretation Of Prostatic Biopsies Has Been A Continuous Problem For Practising Pathologist. Various Types Of Difficulties Have Been Encountered While Diagnosing And Typing Prostatic Carcinoma And Premalignant Lesions Especially In TURP Chips Where There Is Loss Of Orientation And Coagulation Of Tissue During Cauterization. Prostatic Lesions On Routine Haematoxylin & Eosin Staining Sometimes Cause Diagnostic Dilemma Between Benign And Malignant Lesions And Especially In Premalignant Lesions Like Atypical Adenomatous Hyperplasia (AAH) And Prostatic Intraepithelial Neoplasia (PIN). An Important Diagnostic Criteria In The Differentiation Is The Loss Of Basal Cell Layer In Adenocarcinoma And Its Presence In The Benign Lesions. Several Immunohistochemical Markers Have Been Used To Stain The Basal Cells Of Prostate Like High Molecular Weight Cytokeratin (HMWCK), P63 Etc. Proliferative Markers Like Silver Staining Nucleolar Organizer Regions (Agnor), Proliferating Cell Nuclear Antigen (PCNA) Are Of Great Help In Differentiating Benign Premalignant And Malignant Lesions. This Current Study Aims At Analysis Of Histopathological Features Of Various Non Neoplastic And Neoplastic Lesions Of The Prostate Including The Grading Of Malignant Lesions And Evaluation Of Role Of Basal Cell Markers And Proliferative Markers In Different Benign, Premalignant And Malignant Lesions Of Prostate. Histological Typing, Grading And Staging Of Prostatic Carcinoma Are Vital In Planning The Treatment Strategies And Predicting The Survival Rate.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Histopathological Prostatic Lesions ; Assessement Agnor Index ; Prostatic Basal Cell Marker.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 27 Jun 2017 11:27
Last Modified: 27 Jun 2017 11:27
URI: http://repository-tnmgrmu.ac.in/id/eprint/435

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