Shobana, B (2013) Clinicopathological Correlation of Breast Neoplasms with Hormone Receptor Study in Selected Cases. Masters thesis, Madurai Medical college.
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Abstract
Breast Cancer Is A Multifactorial Disease Which Is Having Distinct Biological Subtypes. They Have A Broad Spectrum Of Clinical, Pathological And Molecular Characteristics Resulting In Different Prognostic And Therapeutic Applications. Therefore, Every Lump In The Breast Should Be Considered As A Malignant Lesion Until Proved Otherwise. As Breast Is One Of The Frequent Sites Which Is Under The Influence Of Hormones, Major Hormonal Changes During Adolescent Period, Child Bearing Period And At The Time Of Menopause Will Affect The Mammary Tissue. Breast Cancer Is One Among The Frequently Encountered Malignancies In The World Among Females. There Should Be Enough Knowledge About Its Epidemiology At The Regional As Well As In Worldwide Basis And This Will Provide A Way For Its Effective Control. Many Of The Indian Literature Report That The Age Incidence Of Breast Cancer In The Indian Females Is Somewhat Prior To The Western Population. Among Urban Females, Carcinoma Breast Has Come Up As The Leading Cause Of Cancer-Related Mortality6 And Has Overtaken Carcinoma Cervix. With The Knowledge Of Complexity And Heterogeneity Of Breast Cancers, Intensive Efforts Have Been Undertaken To Study The Correlation Between Clinical Characteristics And The Histopathological As Well As Molecular Features. Also, There Is A Steady And Persistent Work Up In Identifying Certain Predictive Factors To Deal With The Disease Prognosis And Treatment Strategy. In Low And Middle Income Countries, Breast Cancer Related Mortality Has Been In The Range Of 55% Of All New Cases Per Year (Curado Et Al, 2007). In India The Incidence Of Breast Cancer Constitutes About One Third To One Fourth That In USA But Still Stands As The Leading Cause Of Cancer Among Women (Ferlay Et Al, 2004, Datta Et Al 2012). Though The Incidence Is Lower, The Total Number Of Cases And The Mortality Is High Because Of The Population Burden, Insufficient Screening Facilities And Lack Of Education. To Reduce This Increasing Load Of Mortality, We Need To Consider The Importance Of Early Detection And The Availability Of Systemic Therapy And For This, We Should Have A Better Understanding Of The Trend, Age Group Involved And Other Risk Factors. Even If, A Great Advancement Has Emerged In The Management Of Breast Cancer, The Concept In The Management Of Breast Cancer Is To Bring Forward An Individual Based Treatment Plan To Avoid Excessive And Ineffective Treatment That Can Cause Unnecessary Morbidity And Mortality. Estrogen Receptor (ER) Which Has Been Discovered In 196247 Has Become The First Molecule With Great Effectiveness In The Intervention Of Invasive Breast Cancer. Nowadays, Breast Carcinoma Is Considered As A Distinct And Exclusive Disease In Oncology And The Specific Biologic Markers - ER, PR Are Utilised To Predict The Hormonal Response And Serve As A Guide For The Therapeutic Plan. Hormonal Receptor Positive And Negative Cases Have Different Biological Behaviour, Distinct Treatment Protocol And Prognostic Implication. This Study Aims At Correlating The Factors Like Age Of The Patient, Clinical Presentation, Histological Grade, Stage And The Hormonal Receptor Status With Respect To Menopausal Status And Different Histological Types Of Breast Carcinomas. An Attempt Has Been Made To Evaluate The Various Morphological Patterns Of The Malignant Lesions Of The Breast And Their Age Distribution From The Mastectomy Specimens Along With The Axillary Lymph Node Dissection In The Department Of Pathology, Madurai Medical College, Madurai. With The Help Of The Hormonal Receptor (ER, PR) Assessment, The Prognostic Assessment And The Treatment Modality Of Breast Cancer Can Be Done With Precision.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Clinicopathological Correlation ; Breast Neoplasms ; Hormone Receptor Study ; Selected Cases. |
| Subjects: | MEDICAL > Pathology |
| Depositing User: | Subramani R |
| Date Deposited: | 27 Jun 2017 11:28 |
| Last Modified: | 27 Jun 2017 11:28 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/434 |
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