Histopathological Analysis of Association of Papillary Carcinoma Thyroid with Thyroiditis and Other Thyroid Lesions.

Geethalakshmi, S (2010) Histopathological Analysis of Association of Papillary Carcinoma Thyroid with Thyroiditis and Other Thyroid Lesions. Masters thesis, Stanley Medical College, Chennai.

[img]
Preview
Text
200300210geethalakshmi.pdf

Download (403kB) | Preview

Abstract

Papillary Carcinoma Of The Thyroid Is The Most Common Malignant Tumor Of The Thyroid, Accounting For 80% Of All Thyroid Cancers. It Occurs Mostly Commonly In Women Between 3rd To 5th Decades. The Interplay Between Inflammatory And Neoplastic Disorders, Firmly Established In Certain Tissues, Is A Matter Of Controversy In The Thyroid. An Increased Risk For Developing Papillary Carcinoma In Patients With Hashimoto’s Thyroiditis Remains Controversial Ranging From 0-30%1 A Marker Found Frequently In Both Of These Thyroid Disorders Is Described. Expression Of P53 Homologous Nuclear Protein P63 Was Surveyed In A Spectrum Of Thyroid Neoplasms And Inflammatory Disorders. P63 Is Postulated To Regulate The Stem Cell Phenotype In Squamous Epithelia, And In Tumors Of Squamous Origin2. This Work Aims At Histologically Classifying All The Thyroid Lesions And Identifying The Lesions Of Hashimoto’s Thyroiditis With Papillary Carcinoma, And Establishing The Pathobiologic Link Between The Two By Immunohistochemical Detection Of P63 In Papillary Thyroid Carcinoma And Hashimoto’s Thyroiditis. The Expression Of P63 Protein In Hashimoto’s Thyroiditis And Papillary Carcinoma Has Been Studied In This Work To Address The Postulate Of A Common Origin From A Stem Cell Precursor. The Study Herein Describes The Immunohistochemical Detection Of P63 In Papillary Carcinomas Of Thyroid, Hashimoto’s Thyroiditis And Hashimoto’s Thyroiditis With Papillary Carcinoma To Find Out Whether P63 Expression May Constitute A Mechanistic Link Between Hashimoto’s Thyroiditis And Papillary Carcinoma.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Histopathological Analysis ; Association of Papillary Carcinoma Thyroid ; Thyroiditis ; Other Thyroid Lesions.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 27 Jun 2017 11:30
Last Modified: 27 Jun 2017 11:30
URI: http://repository-tnmgrmu.ac.in/id/eprint/422

Actions (login required)

View Item View Item