A Comparative Study of various Forms of Oral Iron and Intramuscular Iron Treatment in Moderately Anaemic Pregnant Women

Shanthi, A (2006) A Comparative Study of various Forms of Oral Iron and Intramuscular Iron Treatment in Moderately Anaemic Pregnant Women. Masters thesis, Madras Medical College, Chennai.


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INTRODUCTION: Anaemia in pregnancy exists world over but it is a very common problem in most of developing countries. Anaemia is major public health problem in economically disadvantaged segments of population in developing countries. In country like India it is frequently severe and contributes to maternal mortality and reproductive healthy morbidity. It deserves more attention than what it is currently receiving. Recently lot of programmes have been focused on safe motherhood but maternal anaemia remains a problem of great concern. Gender discrimination is another important factors in India and other Asian countries the girl child right from birth is denied of proper food and education which leads to iron deficiency anaemia during pregnancy. AIM OF THE STUDY: To compare the efficacy of Various Oral Iron: a. Ferrous sulphate, b. Sodium Feredetate (Sodium Iron EDTA), c. Carbonyl iron. Parental Iron: a) Iron Dextran (Imferon). In moderately anaemic pregnant women belonging to 24 to 32 weeks of gestational age. MATERIALS AND METHODS: The study was conducted from February 2005 – February 2006 in Hospital for Women and Children Egmore (Institute of Obstetrics and Gynaecology) attached to Madras Medical College. The antenatal women attending the antenatal OP are screened for Haemoglobin status. Those antenatal women of gestational age 24 – 32 weeks with hemoglobin between 8- 9.5gm% were selected 200 of those women was selected. Exclusion criteria : i. Women with diabetes, hypertension significant medical complication such as heart disease or any other systemic disease are excluded, ii. Gastro intestinal bleeding or malabsorbtion, Bleeding piles and bleeding from any other site is excluded, iii. Multiple pregnancy, iv. Previous blood transfusion, v. Recent administration of iron for treatment of anaemia. Investigation performed were a) Haemoglobin estimation, b) Peripheral smear study. SUMMARY: Ferrous Sulphate - 70% of the patient had 1 – 1.5 gm% rise in haemoglobin per month. • Sodium Feredetate - 50% of the patient had 1.6 – 2 gm% rise in haemoglobin per month. • Carbonyl iron - 60% of the patient had 1.6 – 2 gm% rise in haemoglobin per month. Parentral iron - 60% of the patient had a rise of 2 – 2.5gm% per month • Parentral group showed a better response than oral group. • Among oral iron, carbonyl iron showed a better response. • Expenditure of treatment was more with carbonyl iron. • Ferrous sulphate was the cheaper iron. • Gastro intestinal side effects was noted in all three groups of oral iron • Pain and discoloration of skin was complained by the parentral group. • Parentral iron administration needs hospitalization and the help of paramedical workers. CONCLUSION: In our study among the oral groups efficacy of carbonyl iron and sodium feredetate is more than ferrous sulphate but the expenditure of treatment is higher than ferrous sulphate which the patients in our setup cannot afford. The ferrous sulphate group showed a 1 – 1.5gm% rise in haemoglobin / month, when screened at a earlier gestational age (24 – 32 weeks) anaemia of moderate grade can be effectively treated with ferrous sulphate at a lower cost. The compliance and efficacy of parentral iron dextran is more than all three oral groups. If the patient cannot tolerate oral iron we can change over to parentral iron which showed a better rise in haemoglobin.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Comparative Study ; various Forms ; Oral Iron ; Intramuscular Iron Treatment ; Moderately Anaemic Pregnant Women.
Subjects: MEDICAL > Obstetrics and Gynaecology
Depositing User: Subramani R
Date Deposited: 03 Dec 2017 09:49
Last Modified: 05 Dec 2017 01:29
URI: http://repository-tnmgrmu.ac.in/id/eprint/4157

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