A Study of Epithelial Ovarian Malignancy and Its Treatment in a Tertiary Hospital

Manjula, S (2006) A Study of Epithelial Ovarian Malignancy and Its Treatment in a Tertiary Hospital. Masters thesis, Madras Medical College, Chennai.

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Abstract

112 patients who had been admitted with Ovarian Cancer at Institute of Obstetrics & Gynecology (IOG) Government Hospital for Women and Children and then registered at Medical Oncology Dept., IOG were analysed. • 88 of 112 patients had Epithelial Ovarian Cancer. 11 of 88 patients were in Early stage had no recurrence till the last day of followed up, to whom no chemotherapy was given and were follow up. • 77 of 88 patients were in Advanced stage . 64 of 77 had Adjuvant chemotherapy with Cisplatin 75 mg. /m2 & Cyclophospamide 750 mg. /m2 given over 3 days every three weekly for a period of 6 cycles. Chemotherapy was started within 14 days of laprotomy. • 13 of 77 patients are treated with Neo Adjuvant chemotherapy with the same dose of chemotherapy for a period of 3 cycles, were followed up. • Median time to progression for disease for 13 women who received Neo Adjuvant Chemotherapy is 9 months versus 9 months for 64 patients who had suboptimal cytoreduction followed with Adjuvant Chemotherapy. • Progression Free survival period for Neo Adjuvant treatment is 14 months when compared with conventionally treated women is 9 months. • Neo adjuvant chemotherapy can be considered to improve the quality of life, surgical results and subsequently the disease progression period. CONCLUSION: Advanced EOC Contributes 87.5% of Ovarian Cancer. • Median time to progression is 9 months following Sub optimal surgery and Adjuvant Chemotherapy. • Progression Free survival period for Neo-Adjuvant treatment is 14 months. when compared with conventionally treated women is 9 months. • Neo adjuvant chemotherapy can be considered to improve the quality of life, surgical results and subsequently the disease progression period.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Epithelial Ovarian Malignancy ; Treatment ; Tertiary Hospital.
Subjects: MEDICAL > Obstetrics and Gynaecology
Depositing User: Subramani R
Date Deposited: 03 Dec 2017 06:19
Last Modified: 05 Dec 2017 00:39
URI: http://repository-tnmgrmu.ac.in/id/eprint/4151

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