Chellammal, K R (2008) Efficacy of single dose vaginal misoprostol 800 μg in First trimester abortion. Masters thesis, Madras Medial College, Chennai.
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Abstract
INTRODUCTION : Medical abortion is a safe effective means of terminating a pregnancy and has been shown to be widely acceptable in both developed and developing countries in all world regions. This method uses pharmacological agents such as mifepristone and misoprostol to expel the contents of the uterus. Used in combination these medications stimulate uterine contractions and causes expulsion of the pregnancy. Misoprostol alone may be useful where mifepristone is not available. The use of Misoprostol alone at the community and primary care levels has the potential to significantly increase, women’s assess to safe abortion. Considerable saving in resources can be made if routine curettage can be avoided and a medical rather than surgical abortion adopted. AIM OF THE STUDY : 1. To evaluate the efficacy of single dose 800 μg of vaginal misoprostol in I trimester pregnancy termination. 2. To critically evaluate the percentage of patients needing multiple doses. 3. To study and evaluate the failure rate, complications and side effects with Misoprostol usage. MATERIALS AND METHODS: This study was carried out in the Department of Obstetrics and Gynaecology, Government Rajaji Hospital, Madurai during the period of February 2007 to July 2007. The purpose of the study was to evaluate the efficacy of single dose 800 μg of vaginal misoprostol in I trimester pregnancy termination. Patient’s Selection Criteria : 50 patients with intra uterine pregnancy up to 12 weeks were randomly selected for the study. The age group was between 20 to 34 years Patient with scarred cervix, previous cervical surgery and previous scar in the uterus and with medical or surgical disease were excluded from the study. Patient informed consent : Written consent of the patients were taken and if the patient was a minor her parents consent was obtained. Patient was given prophylactic antibiotics. SUMMARY: This study was conducted in the Department of Obstetrics and Gynaecology, Government Rajaji Hospital, Madurai between the period of Feb 2007 to July 2007. 50 patients underwent this study. In this study, 78%(39/50) of the patients were between age group of 21-29 years. 50%(25/50) were primi gravida and 50%(25/50) were multigravida. Success rate were unaffected by parity. Majority of the patients were in the gestational age of < 10 weeks 74% of the patients had complete expulsion of products of conception with single dose of 800 ug of vaginal misoprostol 8% of the patients required curettage of the uterine cavity. 18% of the patients required a second dose of 800 ug of vaginal misoprostol. The mean induction abortion interval was 11.38 hrs. Out of 50 cases 9 had minor side effects like vomiting and diarrhea. Hence single dose of vaginal misoprostol (800ug) is found to be effective in I trimester pregnancy termination with minimal side effects. CONCLUSION : Vaginal prostaglandin E1 analogue (misoprostol) is a very safe and effective method of termination of I trimester pregnancy. Single high dose of vaginal misoprostol (800ug) is found to be effective in I trimester pregnancy termination with minimal side effects and shorter duration abortion interval and hospital stay.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Efficacy ; single dose vaginal misoprostol 800 μg ; First trimester abortion. |
| Subjects: | MEDICAL > Obstetrics and Gynaecology |
| Depositing User: | Subramani R |
| Date Deposited: | 28 Nov 2017 02:56 |
| Last Modified: | 09 Dec 2017 03:18 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/4120 |
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