Mean corpuscular volume as a marker of alcohol use disorders

Raja, M (2014) Mean corpuscular volume as a marker of alcohol use disorders. Masters thesis, Madras Medical College, Chennai.


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INTRODUCTION : Alcoholism and related complications are more prevalent world wide. Alcohol use is associated with more than 60 medical conditions. Alcohol use disorders (AUD) generally confirmed by screening test based on questionnaires like AUDIT. Mean Corpuscular Volume also elevated in alcohol use disorders. Aim of this study is to evaluate usefulness of MCV as a marker of AUD. AIMS AND OBJECTIVES : To evaluate the usefulness of mean corpuscular volume to identify alcohol use disorder in comparison with AUDIT (Alcohol Use Disorders Identification Test) screening test. METHODS : Totally 100 patients were evaluated. Patients who were admitted in medical wards of Rajiv Gandhi Government General Hospital, Chennai for found to having alcohol use disorders by AUDIT. Patients history were taken as per the questionnaire and patients were subjected to clinical examinations. Investigations like Complete Blood Count, Peripheral smear, Random Blood Sugar, Blood Urea, Serum Creatinine, Liver Function Test, Thyroid Stimulating Hormone Assay (TSH), USG abdomen also done and results were analysed. RESULTS : Out of 100 patients with AUD, 61 patients had elevated MCV of >100 with statistically significant p value 0.028. 62 patients had elevated AST/ALT ratio of >1. To confirm this findings, large community based trails needed in persons with AUD without other medical comorbidity. CONCLUSION : Diagnosing alcohol injection after development of alcohol dependence or alcohol related problems has no value in the management. A combined use of AUDIT and cost effective investigations like mean corpuscular volume. We can diagnose the problem earlier and we can prevent the complications. Patients with macrocytosis without anaemia should be evaluated for alcohol abuse. Mean Corpuscular volume the only biomarker that reduce long time after alcohol cessation. It has to be studied to follow up of long term abstinence. Large community based studies needed involving alcohol users without complications to find out usefulness of this test.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Alcohol Use Disorders Identification Test, Alcohol Use Disorders, Mean Corpuscular Volume, Aspartate Amino Transferase, Alanine Amino Transferase.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 25 Nov 2017 11:56
Last Modified: 02 Feb 2018 03:07

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