Luijimmala, S (2014) Randomized comparative study of safety and efficacy of oral and vaginal misoprostol in the termination of Second trimester pregnancy over a period of one Year at tertiary care institution. Masters thesis, Kilpauk Medical College, Chennai.
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Abstract
OBJECTIVES: A prospective randomized study was conducted in 72 pregnant women, with the gestational period (between 12 and 20 weeks), to compare the efficacy and safety of oral versus vaginal administration of misoprostol for second trimester pregnancy termination. PLACE & DURATION OF STUDY: The Department of Obstetrics and Gynaecology, Govt. Kilpauk Medical College and Hospital (KMCH), Chennai from November 2012 and November 2013. METHODOLOGY: Women aged 18-38 years requesting MTP for maternal reason, fetal congenital anomalies and intrauterine fetal demise were randomly assigned into two groups. Group A (n=36) had misoprostol orally while the Group B (n=36) received misoprostol by vaginally route. Dosage regimen was similar in both the groups that was 200 μg every 4 hrs until the abortion occurred or maximum up to 6 doses. MAIN OUTCOME MEASURES: Efficacy included induction to delivery interval and safety included maternal complications and side-effects like nausea, vomiting, diarrhoea, fever and abdominal pain and results were compared. RESULTS: The percentage of women who delivered was significantly higher in the vaginal group than the oral group (94.44% vs. 66.67%, P<0.03018) within 24 hrs. The induction to delivery interval and incidence of side-effects were noted. CONCLUSION: Vaginal administration of misoprostol resulted in a higher success rate and misoprostol is safe and effective drug for second trimester pregnancy termination.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Misoprostol ; oral and vaginal route ; second trimester pregnancy termination. |
| Subjects: | MEDICAL > Obstetrics and Gynaecology |
| Depositing User: | Subramani R |
| Date Deposited: | 25 Nov 2017 07:33 |
| Last Modified: | 24 Jun 2018 12:11 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/4058 |
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