Dheepa Jayanthi, R (2013) Iron prophylaxis in pregnancy Intravenous Versus Oral route. Masters thesis, Madras Medical College, Chennai.
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Abstract
In our study 300 Antenatal Women attending the Antenatal out Patient department who fulfill the inclusion criteria were randomly selected and divided into one of the three groups. Initially Hemoglobin, Packed cell volume, Mean corpuscular volume was done in all the Women. Group A and B Women were given two and three doses of intravenous iron sucrose respectively. Group C Women were given oral ferrous sulphate. The following parameters were analysed after 4 weeks, 8 weeks and at term. 1. Hemoglobin in g/dl. 2. Packed cell volume. 3. Mean corpuscular volume. Statistical package for social science (SPSS) was used for statistical compilation and analysis. For Statistical analysis of difference between groups, analyses of covariance or t-test were applied when appropriate. Statistical significance was accepted as P<0.05. The results of the study are tabulated, analysed and summarized as follows; 1. Majority of women 157 (52.3%) belong to the age group between20-24 years. 2. In this study Majority of women 239(79%) belong to Class IV Socioeconomic status. 3. Most of the Women 185 (61.7%) were primipara in our study. 4. The Mean PCV within groups before starting therapy and at term is statistically significant P<0.001. When compared between groups, there is no statistical significance in PCV between intravenous and oral group. 5. The Mean MCV within groups before starting therapy and at term is statistically significant P<0.001. When compared between groups there is no statistically significance in MCV between intravenous and oral group. 6. Mean rise in HB at term is 0.969 in group A, 1.599 in Group B, 0.729 in Group C. There is statistically significant rise in HB fro pretreatment value to HB at term in all the three groups. Group B is statistically significant P<0.000 when compared to Group A and Group C. 7. Only 3.5% of Women had minor drug events in intravenous iron sucrose group. No major Anaphylactic reactions noted during our study. But 25% of Women on Oral iron had side effects of gastrointestinal symptoms. CONCLUSION: 1. From our present study , Intravenous iron sucrose is highly efficacious in improving hemoglobin when compared to oral iron in the prophylaxis of iron deficiency anemia. There is no statistical difference between intravenous group and oral group in terms of packed cell volume, Mean corpuscular volume. 2. Three dose of iron sucrose improves hemoglobin significantly with no serious side effects, compared to two doses of iron sucrose and oral ferrous sulphate in the prophylaxis of iron deficiency anemia in pregnancy. 3. Intravenous iron sucrose was well tolerated and safe and there were no major adverse reactions. To conclude three doses of intravenous iron sucrose is safe, convenient, more effective in the prophylaxis of gestational anemia compared to oral iron. Intravenous Iron sucrose could be a better alternative to oral ferrous sulphate In the prophylaxis of iron deficiency anemia in pregnancy so as to reduce the maternal mortality and morbidity.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Iron prophylaxis ; pregnancy ; intravenous ; Oral Route. |
| Subjects: | MEDICAL > Obstetrics and Gynaecology |
| Depositing User: | Subramani R |
| Date Deposited: | 25 Nov 2017 07:28 |
| Last Modified: | 28 Nov 2017 02:16 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/4055 |
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