Menaka, V (2014) Study of serum lipid profile in gestational hypertension and preeclampsia. Masters thesis, Coimbatore Medical College, Coimbatore.
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Abstract
BACKGROUND: Gestational hypertension and preeclampsia are classified as hypertensive disorders of pregnancy. They are one of the major causes for increased mortality and morbidity in mother and fetus. In these disorders, Placental ischemia and inflammation occur due to impaired trophoblastic invasion into uterine spiral artery. Inflammatory mediators released from ischemic placenta into the circulation lead to insulin resistance and dyslipidemia which further lead to endothelial dysfunction and hypertension. AIM OF THE STUDY: 1. To compare the serum lipid parameters (triglycerides, total cholesterol, LDL, HDL) of normal pregnant women with gestational hypertension and preeclampsia. OBJECTIVES: 1. To measure serum lipid profile in gestational hypertension, preeclampsia and normal pregnant women. 2. To compare serum lipid profile levels in three groups. 3. To know the role of altered lipid profile in the pathophysiology of preeclampsia. 4. To establish the relationship between serum lipid profile and preeclampsia. 5. To correlate the lipid profile levels with the severity of preeclampsia. METHODS: Case control study was done taking 30 women with gestational hypertension as Group-I, 30 women with preeclampsia as Group-II and 30 age matched healthy pregnant women as controls. In all the subjects, concentrations of serum triglycerides, total cholesterol and HDL were estimated using enzymatic methods in semiautoanalyser. LDL calculated by Friedwald's formula using triglyceride, total cholesterol, HDL values. RESULTS: The mean concentrations of triglyceride, total cholesterol, LDL were significantly increased and HDL concentration significantly decreased in women with hypertensive disorders of pregnancy when compared with healthy pregnant women. Systolic blood pressure, diastolic blood pressure and urine albumin have positive correlation with triglyceride concentration. INTERPRETATION AND CONCLUSION: This study suggests that dyslipidemia is present in women with gestational hypertension and preeclampsia. The serum lipid profile in these conditions may help to detect the disease progression. It leads to development strategies to prevent recurrence in next pregnancy by life style modification and medication. As Systolic blood pressure, Diastolic blood pressure and urine albumin have positive correlation with triglyceride concentration it indicates the severity of disease.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Dyslipidemia ; gestational hypertension ; preeclampsia. |
| Subjects: | MEDICAL > Obstetrics and Gynaecology |
| Depositing User: | Subramani R |
| Date Deposited: | 25 Nov 2017 06:39 |
| Last Modified: | 24 Jun 2018 12:25 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/4040 |
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