Prediction of glomerular filtration rate by schwartz formula in children aged 5 - 12 years admitted in an urban referral centre

Suresh Kannan, K (2006) Prediction of glomerular filtration rate by schwartz formula in children aged 5 - 12 years admitted in an urban referral centre. Masters thesis, Madras Medical College, Chennai.


Download (148kB) | Preview


INTRODUCTION: Glomerular filtration rate (GFR) provides an excellent measure of the filtering capacity of the kidneys. Glomerular filtration rate (GFR) is the best estimate of functional renal mass. It is the most widely used indicator of renal function in patients with renal disease. The severity and the prognosis of any renal disease are usually predicted on this parameter. A low or decreasing GFR is a good index of chronic kidney disease. Since the total kidney GFR is equal to the sum of the filtration rates in each of the functioning nephrons, the total GFR can be used as an index of functioning renal mass. A decrease in GFR precedes kidney failure in all forms of progressive kidney disease. Monitoring changes in GFR can delineate progression of kidney disease. The level of GFR is a strong predictor of the time to onset of kidney failure as well as the risk of complications of chronic kidney disease. Additionally, estimation of GFR in clinical practice allows proper dosing of drugs excreted by glomerular filtration to avoid potential drug toxicity. AIM OF THE STUDY: To study the validity / accuracy of Schwartz formula in predicting Glomerular filtration rate (GFR), comparing it with creatinine clearance. MATERIALS AND METHODS: Place of study: Institute of Child Health & Hospital for children, Chennai. Period of study: July 2004 to February 2006. Study Design: Evaluation of a diagnostic modality. Study population: Children aged 5 – 12 years. Inclusion criteria: 1. Children without any evidence of renal disease with normal hydration, 2. Nephrotic syndrome patients, 3. Acute Glomerulonephritis patients, 4. All CRF patients admitted in nephrology ward as predicted by creatinine clearance. Exclusion criteria: Children with obstructive uropathy, neurogenic bladder and voiding dysfunction. SUMMARY AND CONCLUSION: •The Schwartz formula predicts GFR better in children with normal renal function. •In predicting GFR in children with impaired renal function, the Schwartz formula has a sensitivity of 65.8%. a specificity of 94.3%. a positive predictive value of 97.3%. a negative predictive value 46.5%. •There is a significant correlation (r = 0.75) between Schwartz formula and creatinine clearance. To conclude, the Schwartz formula has a sensitivity of 65.8% in detecting children with impaired renal function, and therefore may not be useful as a screening method, and these children may need more accurate methods of estimating GFR.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Prediction ; glomerular filtration rate ; schwartz formula ; children aged 5 - 12 years ; urban referral centre.
Subjects: MEDICAL > Paediatrics
Depositing User: Subramani R
Date Deposited: 25 Nov 2017 03:00
Last Modified: 23 Jul 2018 02:14

Actions (login required)

View Item View Item