Endometrial Carcinoma: A Clinicopathological study

Lakshmi, D (2014) Endometrial Carcinoma: A Clinicopathological study. Masters thesis, Madras Medial College, Chennai.


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INTRODUCTION: Endometrial carcinoma is the fourth most common cancer in females, ranking behind breast, lung and bowel cancers in the Western population. It is the eighth leading cause of death from malignancy in women. It is the most common gynaecological malignancies in Western world. In India, cervical cancer ranks first among gynecological malignancies. However in recent years there is a increasing trend in the incidence of endometrial carcinoma. AIM OF THE STUDY: The aim of our study is to analyze various etiological factors responsible for endometrial carcinoma, to study the various clinical presentations, ideal investigations and management of endometrial carcinoma and assess the outcome of endometrial carcinoma. MATERIALS AND METHODS: All patients who were diagnosed to have endometrial carcinoma by dilatation and curettage or detected after surgery by histopathological examination were enrolled in the study and their clinical profile was analyzed for various demographic details, presenting signs and symptoms, menstrual history, associated medical disorders and family history .Their height, weight, BMI, Clinical examination findings and results of various investigations were tabulated. Details of surgical procedure and intraoperative findings were recorded. Patients were then staged as per FIGO staging and histopathological features were documented. Patients were then either observed as in stage I A or given appropriate adjuvant therapy post operatively with vaginal brachytherapy or chemoradiation for other stages. All patients were followed throughout the study. Data were entered into a standard proforma and analyzed. RESULTS: Risk factors for endometrial carcinoma like early menarche, late menopause, nulliparity, infertility, are not observed among our patients but the incidence is increasing in our population probably because of increased obesity. Endometrioid adenocarcinoma is the most common histologic type noted and most of them presented with stage I disease .2 year survival for endometrial carcinoma is 85% CONCLUSION: To promote healthy lifestyle and decrease incidence of obesity among our population. Post menopausal hormone therapy should used along with progesterone to prevent endometrial stimulation. Early diagnosis and management can improve survival in endometrial carcinoama patients as shown in our study.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Endometrial carcinoma ; obesity ; hysterectomy ; lymphadenectomy ; FIGO Staging.
Subjects: MEDICAL > Obstetrics and Gynaecology
Depositing User: Subramani R
Date Deposited: 25 Nov 2017 02:48
Last Modified: 25 Nov 2017 02:48
URI: http://repository-tnmgrmu.ac.in/id/eprint/4027

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