Comparative histopathology and biochemical analysis of aqueous humor in phacolytic glaucoma and immature cataract

Reetha, B T (2014) Comparative histopathology and biochemical analysis of aqueous humor in phacolytic glaucoma and immature cataract. Masters thesis, Christian Medical College, Vellore.

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Abstract

AIMS & OBJECTIVES: The aim of this study was to characterize Phacolytic glaucoma by doing a comparative study of the clinical features, Ultrasound biomicroscopy and aqueous humor (biochemical & histopathological) study in phacolytic glaucoma and immature cataract and also to study the characteristics of the macrophages in Phacolytic glaucoma using electron microscopy(EM). MATERIAL AND METHODS: This was a case- control study was conducted from December 2012 – November 2013. Patients attending the outpatient department or casualty diagnosed to have phacolytic glaucoma or immature cataract (up to nuclear sclerosis Grade-3), fulfilling the inclusion and exclusion criteria were included in the study. Ultrasound biomicroscopy was performed on all patients at presentation followed by paracentesis to analyse aqueous humor for presence of cells and to estimate protein concentration and results were analyzed. In 3 cases aqueous humor was studied by electron microscopy. RESULTS: Aqueous humor study showed cells in 75% of cases. Neutrophils were seen in 58.3 % and macrophages in 50% of samples. This high incidence of Neutrophils is reported rarely in literature. The protein concentration in cases of phacolytic glaucoma was four times that of controls. Electron microscopy study revealed macrophages as the predominant cell with only 1 monocyte and few neutrophils. UBM revealed AC echoes only in the two cases which had clinically evident fluffy material in the AC.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Phacolytic glaucoma ; Aqueous humor ; Electron microscopy ; Ultrasound biomicroscopy.
Subjects: MEDICAL > Ophthalmology
Depositing User: Devi S
Date Deposited: 16 Nov 2017 11:27
Last Modified: 24 Jun 2018 14:04
URI: http://repository-tnmgrmu.ac.in/id/eprint/3979

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