Keerthana Kumar, N (2013) Expression of Autoreactive B Cell (B-1a) in Periodontal Health and Disease: An Immunohistochemical Study. Masters thesis, Ragas Dental College and Hospital, Chennai.
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Abstract
BACKGROUND: Autoreactive B cell (B-1a) may play a role in the pathogenesis of periodontal disease and this study was undertaken to elicit the autoimmune nature of B-1a cell in periodontal health and disease. MATERIALS AND METHODS: Thirty gingival tissue samples were collected from two groups of patients (periodontal health-Group A and periodontal disease- Group B). The tissue sections were paraffanised and processed. B-1a cell expression in connective tissue was determined using CD5+ as a marker by immunohistochemical analysis. Intensity of staining was assessed and interexaminer error was calculated by kappa analysis. The mean labeling index was statistically analysed using independent ‘t’ test. RESULTS: A good interexaminer agreement was observed between two examiners while assessing intensity. Comparison of mean labeling index between the two study groups was not statistically significant since p value was >0.01 (p value = 0.276). CONCLUSION: An increase in the number of autoreactive B-1a cells (CD5+) has been found in periodontitis as compared to healthy gingival specimens, which was found to be statistically insignificant.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | B-1a cells ; Periodontitis ; Immunohistochemistry. |
| Subjects: | DENTAL > Periodontology |
| Depositing User: | Subramani R |
| Date Deposited: | 13 Nov 2017 17:56 |
| Last Modified: | 13 Nov 2017 17:56 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3939 |
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