Evaluation of Effectiveness of Vitamin C Following Phase I Therapy by Estimating Salivary Superoxide Dismutase Level in Smokers with Chronic Periodontitis.

Kirupa, K (2013) Evaluation of Effectiveness of Vitamin C Following Phase I Therapy by Estimating Salivary Superoxide Dismutase Level in Smokers with Chronic Periodontitis. Masters thesis, Tamilnadu Government Dental College, Chennai.

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Abstract

BACKGROUND: Smoking is an important risk factor for chronic periodontitis (ChP), that induces oxidative stress in the body resulting in an imbalance between Reactive Oxygen Species (ROS) and antioxidants. Use of antioxidant supplementations in humans as an adjunct to periodontal therapy is being one of the innovative strategies in periodontal field.. AIM: To assess the salivary dismutase levels in predicting the effectiveness of vitamin C supplementation in phase I therapy in smokers and non smokers with ChP. MATERIALS AND METHODS: In the present study, a total of 70 male subjects were included, among them 10 were periodontally healthy controls (group I), remaining 60 subjects with chronic periodontitis were divided into two groups, Group II non-smokers with chronic periodontitis and Group III smokers with chronic periodontitis consisting of 30 subjects in each group. Group II and group III were further divided based on the interventional treatment provided. Subjects treated with SRP alone were designated as group IIA and group IIIA and those treated with SRP and adjunct vitamin C were designated as group IIB and group IIIB. The salivary SOD levels were measured at baseline and after one month of treatment using spectrophotometry. RESULTS: Baseline salivary SOD level was significantly less in smokers than non-smokers with ChP as compared to control group. There was a significant reduction in all clinical parameters in smokers and non-smokers with ChP one month following SRP. Salivary SOD level significantly increased (p<0.01) in smokers and non-smokers with ChP one month following SRP supplemented with vitamin C. CONCLUSION: Adjunctive dose of vitamin C has improved salivary SOD level in smokers and non-smokers with chronic periodontitis than SRP alone. Further longitudinal studies may be needed for the administration of vitamin C as an adjunct to periodontal therapy in order to maintain a stable periodontium.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Superoxide Dismutase ; Vitamin C ; Chronic Periodontitis.
Subjects: DENTAL > Periodontology
Depositing User: Subramani R
Date Deposited: 13 Nov 2017 17:31
Last Modified: 13 Nov 2017 17:31
URI: http://repository-tnmgrmu.ac.in/id/eprint/3934

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