Evaluation of Serum Adiponectin Levels in Type II Diabetes Mellitus with Chronic Periodontitis: An Interventional Study

Kannan, C (2013) Evaluation of Serum Adiponectin Levels in Type II Diabetes Mellitus with Chronic Periodontitis: An Interventional Study. Masters thesis, Tamilnadu Government Dental College, Chennai.

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Abstract

BACKGROUND: Chronic periodontitis is primarily an infection wherein pro-inflammatory cytokines are instrumental in host mediated tissue destructive immune response. Among the cytokines, Tumor necrosis factor-α (TNF-α) has been considered to cause insulin resistance. In type-2 diabetes mellitus, insulin resistance is the main etiological factor which is linked to decreased serum adiponectin level, which has been found recently. Many studies have hypothesized that non-surgical periodontal therapy improves glycemic control and adiponectin level in type-2 diabetes mellitus with chronic periodontitis. AIM: To evaluate the effect of non-surgical periodontal therapy on serum adiponectin level in Type-II diabetic patients with moderate to severe chronic periodontitis. METHODS: 50 systemically healthy age & gender matched controls with healthy periodontium and 50 type-2 diabetes mellitus patients with moderate to severe chronic periodontitis were enrolled. Venous blood samples were collected at baseline from 100 subjects (Control group and Study group-I) and 3 months after the non-surgical therapy from diabetic patients with moderate to severe chronic periodontitis (Study group-II). Serum level of adiponectin was analysed by Enzyme linked immunosorbent assay (ELISA). RESULTS: The study group-II showed significant (p=0.000) improvement in clinical periodontal parameters 3 months after the non-surgical therapy. After 3 months, Fasting blood sugar level was significantly (p=0.000) decreased and serum adiponectin level was significantly (p=0.000) increased (8.39μg/mL) in study group-II compared to those in the study group-I (7.52μg/mL). CONCLUSION: In the present study, type-2 diabetes mellitus patients with moderate to severe chronic periodontitis exhibited improvement compared to baseline value. Nonsurgical periodontal therapy improves fasting blood sugar level with elevation of serum adiponectin level in type-2 diabetic patients with moderate to severe chronic periodontitis.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Adiponectin ; Chronic periodontitis ; Type-2 diabetes mellitus.
Subjects: DENTAL > Periodontology
Depositing User: Subramani R
Date Deposited: 13 Nov 2017 17:28
Last Modified: 13 Nov 2017 17:28
URI: http://repository-tnmgrmu.ac.in/id/eprint/3933

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