Formulation and In Vitro Evaluation of Lamivudine and Zidovudine Controlled Release Bilayer Matrix Tablets.

Sachin Vitthal, Gowardipe (2012) Formulation and In Vitro Evaluation of Lamivudine and Zidovudine Controlled Release Bilayer Matrix Tablets. Masters thesis, J.K.K. Nattraja College of Pharmacy, Komarapalayam, Tamil Nadu, India.


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In June 2006, a cumulative total of approximately 80 000 cases of HIV infection had been reported in the UK and 21 000 of these individuals had acquiredimmunodeficiency syndrome (AIDS), of whom 80% had died. Approximately 7500 new cases of HIV were reported in the UK in 2005. The most recent World Health Organization (WHO) report estimated that 38.6 million adults and 2.3 million children world-wide were living with HIV at the end of 2005. Globally, heterosexual transmission accounts for 85% of HIV infections. During 2005, an estimated 4.1 million became newly infected with HIV and an estimated 3 million people died from AIDS. World-wide, the HIV incidence rate is believed to have peaked in the late 1990s and to have stabilized subsequently, notwithstanding an increasing incidence in South-East Asia and China. The study was undertaken with the aim to formulate the Lamivudine and Zidovudine controlled release bilayer matrix tablets by using different grades of polymer like HPMC (K100 and K 15) at different concentrations. The polymer HPMC K 15 used in the formulation (LF5+ZF5) at 25%w/w of the drug showed the better controlled drug release ( Lamivudine= 97.79% w/v and Zidovudine=98.68% w/v) upto 12 hrs. This was selected as the best formulation. This formulation was reduce the frequent dosing, release the drug at controlled manner, increase efficacy, reduces the side effect and improved the patient’s compliance. This combination reduces the risk of emergence of resistance to anti-retroviral drugs. As it fulfills all the requirements of controlled release tablets and this study encourages further clinical trials and long term stability study for best formulation.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Formulation; In Vitro; Evaluation; Lamivudine; Zidovudine; Controlled Release; Bilayer Matrix Tablets
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ravindran C
Date Deposited: 25 Jun 2017 09:30
Last Modified: 25 Jun 2017 09:30

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