Nithya, S (2013) Expression of Loricrin in Oral Submucous Fibrosis, Hyperkeratosis and Normal Mucosa: An Immunohistochemical Study. Masters thesis, Ragas Dental College and Hospital, Chennai.
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Abstract
BACK GROUND : Loricrin is a late differentiation protein of terminally differentiated keratinocytes seen in the cornified envelope. It is seen in abundance in the keratinizing epithelium, which are subjected to considerable mechanical stress. The coarse fibres of areca nut and the continuous friction from occluding teeth are the major causes of mechanical stress to the oral mucosa in oral submucous fibrosis and hyperkeratosis respectively. This study tries to relate the expression of loricrin in these two lesions to the habit of chewing and also its role as a potential marker to diagnose these conditions.. AIM AND OBJECTIVES : To evaluate the expression of Loricrin in the epithelium of formalin fixed, paraffin embedded tissue specimens of oral submucous fibrosis, hyperkeratosis and normal mucosa by immuno histochemistry. MATERIALS AND METHODS : Archival samples of tissue specimens (n=73), which were formalin fixed and paraffin embedded were stained with antibodies to loricrin and the intensity of staining was graded as (-) negative, (+) mild,(++)moderate and (+++) intense. Pearson’s chi square test was done for statistical analysis. RESULTS AND CONCLUSION : Loricrin expression was observed in all the groups with prominent staining in the stratum granulosum and had a significant association to habits.(P=0.000).The prominent staining indicates a compensatory mechanism in the surface of the epithelium in the early stages of oral submucous fibrosis and has the potential to be an early marker of the condition.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Loricrin ; OSF ; Areca nut Hyperkeratosis. |
| Subjects: | DENTAL > Oral Pathology and Microbiology |
| Depositing User: | Subramani R |
| Date Deposited: | 12 Nov 2017 13:38 |
| Last Modified: | 12 Nov 2017 13:38 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3906 |
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